Document Detail


Low heritability of tinnitus: results from the second Nord-Tr?ndelag health study.
MedLine Citation:
PMID:  20157066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate the heritability of tinnitus. DESIGN: Self-report questionnaire data collected from August 1, 1995, through June 30, 1997, from individuals in the Nord-Tr?ndelag Hearing Loss Study (an integrated part of the Nord-Tr?ndelag Health Study) were used. The study also included information on first-degree family relationships, and age-corrected polychoric correlations of relatives' tinnitus status were calculated. A structural equation model was fit to the data, and the relative contributions of genes and unique environmental effects were estimated. Models that included sex-specific effects were also tested. SETTING: Nord-Tr?ndelag County, Norway. PATIENTS: A population-based sample of 12 940 spouses, 27 607 parent-offspring, and 11 498 siblings was used. A total of 28 066 respondents were tested twice, yielding a test-retest correlation of 0.65 for the report of tinnitus. MAIN OUTCOME MEASURE: Heritability of tinnitus. RESULTS: Correlations for parent-offspring ranged from 0.01 to 0.07 for the various sex combinations, sibling correlation ranged from 0.06 to 0.14, and the spouse correlation was 0.04. This family correlation pattern implies an upper limit for heritability of 0.11 with no sex differences in the heritability estimates. CONCLUSIONS: This is the first large population-based family study, to our knowledge, to report on the heritability of tinnitus. In contrast to previous speculations in the literature, this low heritability indicates that additive genetic effects explain only a small proportion of the variance of tinnitus in the population.
Authors:
Ellen Kvestad; Nikolai Czajkowski; Bo Engdahl; Howard J Hoffman; Kristian Tambs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  136     ISSN:  1538-361X     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-82     Citation Subset:  AIM; IM    
Affiliation:
Norwegian Institute of Public Health, Oslo, Norway. ellen.kvestad@fhi.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Models, Theoretical
Norway
Nuclear Family
Questionnaires*
Tinnitus / genetics*
Young Adult
Grant Support
ID/Acronym/Agency:
N01-DC-6-2104/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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