Document Detail

Low hemoglobin levels during normovolemia are associated with electrocardiographic changes in pigs.
MedLine Citation:
PMID:  20856175     Owner:  NLM     Status:  In-Data-Review    
We studied whether low hemoglobin concentrations during normovolemia change the myocardial electrical current (electrocardiogram) in a pig model. Normovolemic anemia was achieved by stepwise replacing blood with colloids (hydroxyethyl starch 6%). We measured the length of the PQ-, QT-, QTc, and the ST interval as well as the amplitude of the Q wave and T wave at hemoglobin concentrations of 9.5, 8.0, 5.5, 3.8, and 3.3 g·dL. Normovolemic anemia is accompanied by a gradual prolongation of the QT and QTc interval and a reduction in the amplitude of the T wave. The QRS complex is partly diminished in amplitude. Results were verified performing a time-frequency analysis on single heartbeats. During severe anemia and normovolemia, electrocardiographic changes can be detected. Further investigations are warranted to elucidate whether these changes indicate myocardial hypoxia.
Bertram Scheller; Gordon Pipa; Harry Kertscho; Patrick Lauscher; Joachim Ehrlich; Oliver Habler; Kai Zacharowski; Jens Meier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  35     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
*Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt; †Department of Neurophysiology, Max Planck Institute for Brain Research; ‡Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University; §Division of Cardiology, Department of Medicine, University Hospital Frankfurt; and ∥Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital Nordwest, Frankfurt, Germany.
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