| Low hemoglobin levels during normovolemia are associated with electrocardiographic changes in pigs. | |
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MedLine Citation:
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PMID: 20856175 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We studied whether low hemoglobin concentrations during normovolemia change the myocardial electrical current (electrocardiogram) in a pig model. Normovolemic anemia was achieved by stepwise replacing blood with colloids (hydroxyethyl starch 6%). We measured the length of the PQ-, QT-, QTc, and the ST interval as well as the amplitude of the Q wave and T wave at hemoglobin concentrations of 9.5, 8.0, 5.5, 3.8, and 3.3 g·dL. Normovolemic anemia is accompanied by a gradual prolongation of the QT and QTc interval and a reduction in the amplitude of the T wave. The QRS complex is partly diminished in amplitude. Results were verified performing a time-frequency analysis on single heartbeats. During severe anemia and normovolemia, electrocardiographic changes can be detected. Further investigations are warranted to elucidate whether these changes indicate myocardial hypoxia. |
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Authors:
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Bertram Scheller; Gordon Pipa; Harry Kertscho; Patrick Lauscher; Joachim Ehrlich; Oliver Habler; Kai Zacharowski; Jens Meier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 35 ISSN: 1540-0514 ISO Abbreviation: Shock Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: United States |
Other Details:
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Languages: eng Pagination: 375-81 Citation Subset: IM |
Affiliation:
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*Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt; †Department of Neurophysiology, Max Planck Institute for Brain Research; ‡Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University; §Division of Cardiology, Department of Medicine, University Hospital Frankfurt; and ∥Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital Nordwest, Frankfurt, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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