| Low hemoglobin density potential marker of iron availability. | |
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MedLine Citation:
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PMID: 21722324 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Low hemoglobin density (LHD%) is a new parameter provided by Beckman-Coulter derived from the mean cell hemoglobin concentration, using the mathematical sigmoid transformation [Formula: see text] This study investigated the reliability of LHD% for the assessment of iron status in the presence of inflammation. Methods: Healthy subjects (n = 90) and patients with iron deficiency (IDA, n = 110), chronic kidney disease (CKD, n = 65) and anemia of chronic disease (ACD, n = 85; 24 were iron deficient and 61 were iron sufficient) were analyzed on a LH 780 analyzer (Beckman Coulter Inc., Miami, FL, USA). Independent samples U test and receiver operating characteristic (ROC) curve analysis were applied. To determine the concordance between LHD% and soluble transferrin receptor (sTrR) Cohen's κ index was calculated. Results: LHD % values showed no statistical difference in patients with IDA and patients with ACD accompanied with IDA (P = 0.6427); LHD% values in these patients were significantly different (P < 0.0001) compared with the iron-sufficient patients with ACD. ROC analysis for LHD% in the detection of iron deficiency showed the following: area under curve 0.903; cut off 5.5%, sensitivity 88.6%, specificity 76.9%; κ index, 0.65. Conclusion: LHD% is a reliable parameter for the detection of iron deficiency in patients with anemia in the presence of inflammation. |
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Authors:
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E Urrechaga; M Unceta; L Borque; J F Escanero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-4 |
Journal Detail:
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Title: International journal of laboratory hematology Volume: - ISSN: 1751-553X ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300213 Medline TA: Int J Lab Hematol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Hematology Laboratory, Hospital Galdakao - Usansolo, Galdakao, Spain Biochemistry Laboratory, Hospital Galdakao - Usansolo, Galdakao, Spain Department of Pharmacology and Physiology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. |
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