Document Detail

Low-grade pulmonary mucosa-associated lymphoid tissue lymphoma with or without intraclonal variation.
MedLine Citation:
PMID:  9817716     Owner:  NLM     Status:  MEDLINE    
We examined the immunoglobulin heavy chain variable (Ig VH) region genes of 11 low-grade pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas by a two-step polymerase chain reaction (PCR) and sequencing analysis. We observed frequent somatic mutations with the positive selective pressure of the rearranged Ig VH genes in all cases, indicative of postgerminal center cell origin. Eight cases demonstrated intraclonal variations (hypermutation with intraclonal variation type), but the other cases showed only one major clone without intraclonal heterogeneity (hypermutation without intraclonal variation type). The former might reflect the reentry of marginal zone B cells into a germinal center environment leading to further mutations. The latter might be no longer susceptible to hypermutation mechanisms and seemed to be stable. Four cases used Ig VH genes (hv3019b9, VH26, and VH4.21), which are frequently found in a variety of autoantibodies, such as cold agglutinins, rheumatoid factors, and anti-DNA antibodies.
K Kurosu; N Yumoto; M Furukawa; T Kuriyama; A Mikata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  158     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1613-9     Citation Subset:  AIM; IM    
The First Department of Pathology and Department of Chest Medicine, School of Medicine, Chiba University, Chiba, Japan.
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MeSH Terms
Aged, 80 and over
Agglutinins / genetics
Antibodies, Antinuclear / genetics
Autoantibodies / genetics
B-Lymphocytes / metabolism,  pathology
Clone Cells
Gene Rearrangement
Genes, Immunoglobulin / genetics
Genetic Predisposition to Disease
Genetic Variation / genetics*
Germinal Center / pathology
Hemagglutinins / genetics
Immunoglobulin Heavy Chains / genetics
Lung Neoplasms / genetics*
Lymphoma, B-Cell, Marginal Zone / genetics*
Middle Aged
Mutation / genetics
Polymerase Chain Reaction
Rheumatoid Factor / genetics
Sequence Analysis
Reg. No./Substance:
0/Agglutinins; 0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Cryoglobulins; 0/Hemagglutinins; 0/Immunoglobulin Heavy Chains; 0/cold agglutinins; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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