Document Detail

Low-grade nonintestinal sinonasal adenocarcinoma: a diagnosis of exclusion.
MedLine Citation:
PMID:  21393036     Owner:  NLM     Status:  Publisher    
The World Health Organization classifies primary sinonasal adenocarcinomas (SNACs) into salivary and nonsalivary types. Salivary types are usually well-defined myoepithelial neoplasms, which closely resemble their salivary counterparts. Nonsalivary types are separated into intestinal-type SNAC (ITAC) and non-ITAC, and both have low- and high-grade categories. Intestinal-type SNACs are aggressive tumors that resemble intestinal epithelium and often arise in the ethmoid sinus. Non-ITACs are of presumed seromucous gland origin, have marked morphologic heterogeneity, and can arise anywhere in the sinonasal tract. Moreover, ITACs typically demonstrate an intestinal-type immunohistochemical profile (CK20+, CK7-, CDX2+, and villin+), whereas non-ITACs reveal a respiratory-type profile (CK20-, CK7+, CDX2-, and villin-). Here, we present a case of low-grade, nonintestinal SNAC in a 17-year-old African American man and a discussion of the classification and pathologic features of primary SNACs.
Feriyl Bhaijee; Jeffrey Carron; Diana Bell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-9
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  -     ISSN:  1532-8198     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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