Document Detail


Low-grade endotoxemia in patients with severe autism.
MedLine Citation:
PMID:  20097267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to examine whether levels of endotoxin and other markers of immuno-inflammatory activation are altered in adult patients with severe autism. We determined circulating serum endotoxin levels, its soluble receptor (sCD14), and markers of immuno-inflammatory activation (IL-1beta, IL-6, and IL-10) in 22 adult patients with severe autism and 28 age- and gender-matched healthy controls. Compared with healthy subjects, serum levels of endotoxin were significantly higher in autistic patients and inversely and independently correlated with Socialization scores on the Vineland Adaptive Behavior Scales (VABS) and ADI-R Domain A score (social). Whether increased endotoxin may contribute to the pathophysiology of inflammation and impaired reciprocal social interaction in autism should be further explored in future studies.
Authors:
Enzo Emanuele; Paolo Orsi; Marianna Boso; Davide Broglia; Natascia Brondino; Francesco Barale; Stefania Ucelli di Nemi; Pierluigi Politi
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Publication Detail:
Type:  Journal Article     Date:  2010-01-25
Journal Detail:
Title:  Neuroscience letters     Volume:  471     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  162-5     Citation Subset:  IM    
Affiliation:
Department of Health Sciences, Section of Psychiatry, University of Pavia, Via Bassi, 21, I-27100, Pavia, Italy. enzo.em@libero.it <enzo.em@libero.it>
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD14 / blood
Autistic Disorder / blood,  complications*,  immunology
Endotoxemia / blood,  complications*,  immunology
Endotoxins / blood
Female
Humans
Immunity, Innate
Interleukin-10 / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Male
Severity of Illness Index
Social Behavior
Young Adult
Chemical
Reg. No./Substance:
0/Antigens, CD14; 0/Endotoxins; 0/Interleukin-1beta; 0/Interleukin-6; 130068-27-8/Interleukin-10

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