| Low-grade chronic inflammation is not accompanied by structural arterial injury in polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 18499295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the presence of premature subclinical atherosclerosis, measured by examining carotid intima-media thickness (IMT) and to investigate whether the IMT may be linked to low-grade chronic inflammation, assessed by C-reactive protein (CRP), in young women with polycystic ovary syndrome (PCOS). METHODS: Fifty seven PCOS patients and 37 similarly aged and weight controls underwent B-mode ultrasonography of the carotid arteries for IMT measure. All these women were also screened for CRP and metabolic parameters including fasting insulin, glucose, lipid and androgen levels. Differences between means were analyzed by Student's unpaired t-test and analysis of correlations between parameters was performed by using Pearson's correlation. RESULTS: CRP was significantly higher in PCOS patients than in controls (3.1mg/dL vs. 1.4mg/dL; p=0.004). No difference was noted in IMT mean between PCOS cases and controls (0.52mm vs. 0.53mm; p=0.35). IMT did not correlate with CRP but exhibited a significant positive correlation with total testosterone (r=0.72, p=0.01). CONCLUSION: This study suggests that PCOS itself is not associated with structural arterial injury, carotid IMT is not linked to low-grade chronic inflammation and hyperandrogenism may be associated with subclinical atherosclerosis and cardiovascular risk in young women with PCOS. Additional research is needed to clarify these findings. |
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Authors:
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Laura Olinda Bregieiro Fernandes Costa; Mayra Pereira dos Santos; Mônica Oliveira; Aline Viana |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-21 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 81 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 179-83 Citation Subset: IM |
Affiliation:
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Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil. heliolaura@yahoo.com.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arteries / injuries, pathology* Blood Pressure Body Mass Index C-Reactive Protein / metabolism Cross-Sectional Studies Female Humans Inflammation / epidemiology* Polycystic Ovary Syndrome / pathology, physiopathology* Reference Values |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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