Document Detail

Low grade cervical intraepithelial neoplasia associated with human papillomavirus infection. Long-term follow-up.
MedLine Citation:
PMID:  9622679     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the correlation between the development of low grade cervical intraepithelial neoplasia (LCIN) and human papillomavirus (HPV) infection in cases with long-term follow-up. STUDY DESIGN: Forty-three cases of LCIN were followed for more than five years with cytology, colposcopy and Vira Pap. Coexistence of HPV infection was sought using a simplified HPV detection kit, the Vira Pap method (Dot Blot hybridization). RESULTS: Regressive disease was noted in 21 cases, and persistent and progressive disease was noted in 22 cases. HPV DNA was negative in 81% (17 of 21) of regressive disease and positive in 55% (12 of 22) persistent and progressive disease. LCIN had disappeared in 17 (63%) of 27 cases negative for HPV DNA and was persistent or progressive in 12 (75%) of 16 cases positive for HPV DNA. CONCLUSION: The clinical course of LCIN correlates well with HPV infection.
Y Matsuura; T Kawagoe; N Toki; K Sugihara; M Kashimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  42     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-06-18     Completed Date:  1998-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-30     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Kitakyushu, Japan.
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MeSH Terms
Cervical Intraepithelial Neoplasia / epidemiology*,  pathology,  virology
DNA Probes, HPV
DNA, Viral / analysis
Disease Progression
Follow-Up Studies
Nucleic Acid Hybridization
Papillomaviridae / isolation & purification*
Papillomavirus Infections / epidemiology*,  pathology
Tumor Virus Infections / epidemiology*,  pathology
Uterine Cervical Neoplasms / epidemiology*,  pathology,  virology
Vaginal Smears
Reg. No./Substance:
0/DNA Probes, HPV; 0/DNA, Viral

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