| Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report. | |
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MedLine Citation:
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PMID: 19936608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy. |
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Authors:
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Robert Corns; Matthew Crocker; Atul Kumar; Jon Salisbury; Christos Tolias; Gill Sadler; Mark Hill |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-11-20 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 152 ISSN: 0942-0940 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 1075-7 Citation Subset: IM |
Affiliation:
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Departments of Neurosurgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK. cilfodan@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimetabolites, Antineoplastic / adverse effects, therapeutic use* Antineoplastic Agents, Hormonal / therapeutic use Biopsy Cerebellar Neoplasms / diagnosis, drug therapy*, pathology, radiotherapy* Cerebellum / pathology Combined Modality Therapy Cranial Irradiation* Dexamethasone / therapeutic use Dose-Response Relationship, Drug Female Humans Infusions, Intravenous Ki-67 Antigen / analysis Lymphoma, T-Cell / diagnosis, drug therapy*, pathology, radiotherapy* Magnetic Resonance Imaging Methotrexate / adverse effects, therapeutic use* Neurologic Examination Radiotherapy, Adjuvant Tomography, X-Ray Computed Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents, Hormonal; 0/Ki-67 Antigen; 0/Tumor Markers, Biological; 50-02-2/Dexamethasone; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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