Document Detail

Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report.
MedLine Citation:
PMID:  19936608     Owner:  NLM     Status:  MEDLINE    
Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy.
Robert Corns; Matthew Crocker; Atul Kumar; Jon Salisbury; Christos Tolias; Gill Sadler; Mark Hill
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-11-20
Journal Detail:
Title:  Acta neurochirurgica     Volume:  152     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1075-7     Citation Subset:  IM    
Departments of Neurosurgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
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MeSH Terms
Antimetabolites, Antineoplastic / adverse effects,  therapeutic use*
Antineoplastic Agents, Hormonal / therapeutic use
Cerebellar Neoplasms / diagnosis,  drug therapy*,  pathology,  radiotherapy*
Cerebellum / pathology
Combined Modality Therapy
Cranial Irradiation*
Dexamethasone / therapeutic use
Dose-Response Relationship, Drug
Infusions, Intravenous
Ki-67 Antigen / analysis
Lymphoma, T-Cell / diagnosis,  drug therapy*,  pathology,  radiotherapy*
Magnetic Resonance Imaging
Methotrexate / adverse effects,  therapeutic use*
Neurologic Examination
Radiotherapy, Adjuvant
Tomography, X-Ray Computed
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Antineoplastic Agents, Hormonal; 0/Ki-67 Antigen; 0/Tumor Markers, Biological; 50-02-2/Dexamethasone; 59-05-2/Methotrexate

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