Document Detail

Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial.
MedLine Citation:
PMID:  24449169     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low-frequency, bilateral stimulation of the subthalamic nucleus can improve axial symptoms of advanced Parkinson's disease (PD), but it is not particularly effective for segmental symptoms.
METHODS: The optimal contacts for low-frequency (60 Hz) and high-frequency (130 Hz) single monopolar stimulation were determined. Then, in a randomized, double-blind, prospective crossover manner, 60-Hz and 130-Hz stimulations via the respective optimal contacts were compared for immediate efficacy in improving the motor function of patients with PD.
RESULTS: The optimal contacts for 60-Hz stimulation were situated more ventrally than those for 130-Hz stimulation (P = 0.038). Under the respective optimal, single monopolar stimulation, 60 Hz provided superior efficacy over 130 Hz in improving the total Unified Parkinson's Disease Rating Scale motor score (P < 0.001) and the akinesia (P = 0.011) and axial motor signs (P = 0.012) subscores without compromising the therapeutic effect on tremor and rigidity.
CONCLUSIONS: Low-frequency stimulation via the optimal contacts is effective in improving overall motor function of patients with PD.
Hui Ming Khoo; Haruhiko Kishima; Koichi Hosomi; Tomoyuki Maruo; Naoki Tani; Satoru Oshino; Toshio Shimokawa; Masaru Yokoe; Hideki Mochizuki; Youichi Saitoh; Toshiki Yoshimine
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2014-01-21
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  29     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-03-04     Completed Date:  2014-10-29     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-4     Citation Subset:  IM    
Copyright Information:
© 2014 Movement Disorder Society.
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MeSH Terms
Cross-Over Studies
Deep Brain Stimulation / methods*
Double-Blind Method
Outcome Assessment (Health Care)
Parkinson Disease / therapy*
Statistics, Nonparametric
Subthalamic Nucleus / physiology*
Comment In:
Mov Disord. 2014 Feb;29(2):161-3   [PMID:  24591170 ]
Mov Disord. 2014 Oct;29(12):1569-70   [PMID:  24985160 ]
Mov Disord. 2014 Oct;29(12):1569   [PMID:  24989692 ]

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