Document Detail


Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: a case-control study.
MedLine Citation:
PMID:  16053398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concern exists about the risk of nephrotoxicity using tenofovir (TDF) in HIV-infected patients. We performed a retrospective case-control study including 122 consecutive TDF-naive patients who started treatment with TDF-containing regimens and 194 patients receiving antiretroviral therapy with other antiretroviral drugs. During a 12-month observation period 5 (4.1%) patients in the TDF group versus 1 (0.5%) in the control group developed grade 1 or higher serum creatinine elevations (p = 0.018). Only 2 (1.6%) patients discontinued TDF treatment as a result of serum creatinine level elevations. In 4 of the 5 patients developing creatinine elevations TDF was combined with lopinavir-ritonavir. The use of TDF in clinical practice during a 12-month period is associated with low risk of mild renal failure. Further studies to assess long-term renal safety of this drug are needed.
Authors:
Sergio Padilla; Félix Gutiérrez; Mar Masiá; Víctor Cánovas; Carmen Orozco
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS patient care and STDs     Volume:  19     ISSN:  1087-2914     ISO Abbreviation:  AIDS Patient Care STDS     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607225     Medline TA:  AIDS Patient Care STDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-4     Citation Subset:  X    
Affiliation:
Infectious Diseases Unit, Internal Medicine Department, Hospital General Universitario de Elche, Alicante, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adenine / adverse effects,  analogs & derivatives*,  therapeutic use
Antiretroviral Therapy, Highly Active / adverse effects,  methods
Case-Control Studies
Creatinine / analysis
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
HIV Infections / diagnosis,  drug therapy*
Humans
Incidence
Kidney / drug effects
Kidney Diseases / chemically induced*,  epidemiology
Kidney Function Tests
Male
Phosphonic Acids / adverse effects*,  therapeutic use
Probability
Prognosis
Reference Values
Retrospective Studies
Reverse Transcriptase Inhibitors / adverse effects*,  therapeutic use
Risk Assessment
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 60-27-5/Creatinine; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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