Document Detail

Low-frequency diaphragmatic fatigue in spontaneously breathing humans.
MedLine Citation:
PMID:  3372425     Owner:  NLM     Status:  MEDLINE    
We used transdiaphragmatic peak twitch tension (PTT) elicited by bilateral phrenic nerve stimulation to ascertain whether low-frequency (LF) diaphragmatic fatigue (DF) can be induced in spontaneously breathing humans by a combination of an inspiratory resistive load (IRL) and graded treadmill exercise (GXT). Our subjects were 10 young males with normal cardiopulmonary function. Before exercise we measured PTT in each subject by administering supramaximal electrical pulses of 100-microseconds duration at a frequency of 1 Hz to each phrenic nerve with the subjects breath holding at functional residual capacity at a given thoracoabdominal configuration. A minimum of six satisfactory PTT measurements were made in each subject, and we computed the 95% confidence limits (CL) for each subject. The subjects then inspired through a resistive load of 38 cmH2O.1(-1).s-1 while carrying out the GXT until exhaustion. After the GXT, PTT was remeasured in all subjects. In five of the subjects, the post-GXT mean PTT fell below the 95% CL of the pre-GXT mean PTT. However, post-GXT PTT means for the other five subjects were within the 95% CL of the pre-GXT means. In conclusion, using PTT as a measure of LFDF, these results demonstrate that LFDF can be produced in 50% of spontaneously breathing young normal males.
S Levine; D Henson
Related Documents :
22847995 - Pilot, randomized trial of resistance exercise during radiation therapy for head and ne...
10194195 - External thoracic restriction, respiratory sensation, and ventilation during exercise i...
12794675 - The distribution of mitochondria-rich cells in the gills of air-breathing fishes.
12527965 - Increased sensations of intensity of breathlessness impairs maintenance of intense inte...
16304295 - Tissue doppler-derived indices predict exercise capacity in patients with apical hypert...
17111315 - Evidence of decrease in peak heart rate in acute hypoxia: effect of exercise-induced ar...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  64     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  672-80     Citation Subset:  IM; S    
Pulmonary Disease Section, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diaphragm / physiopathology*
Fatigue / physiopathology*
Physical Exertion*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Carotid body excision significantly changes ventilatory control in awake rats.
Next Document:  Bolus technique for assessing distribution of inspired gas during tidal breathing.