| Low frequency of cytomegalovirus infection during exacerbations of inflammatory bowel diseases. | |
| | |
MedLine Citation:
|
PMID: 20827767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although numerous reports have described inflammatory bowel diseases (IBDs) complicated with cytomegalovirus (CMV) infection, the virus participation as an exacerbating factor remains unclear. The aim of this study was thus to clarify the clinical significance of CMV infection complicating exacerbation and to correlate CMV detection with various characteristics in IBD patients. Sixty-seven colonic biopsies obtained from 53 patients admitted for IBD exacerbation were retrospectively analyzed by real-time PCR assay. The CMV genome was detected in seven (10.4%) colonic biopsies related to seven patients (three ulcerative colitis and four Crohn's diseases). Among the patients with IBD studied, patients with evidence of CMV infection were older (P = 0.047), were more likely male gender (relative risk [RR] 4.48; 95% confidence interval [CI] 0.94-21.36), received corticosteroids (RR 3.2; CI 0.79-13.02) or azathioprine (RR 3.17; CI 0.80-12.57) treatments, presented more extended lesions (RR for rectum-sigmoid-left colon 3.75 (0.0-69.37) and for pancolitis 2.45 (0.36-16.23)), and had a more severe disease (RR 3.3; CI 0.87-12.48) than those without CMV infection. Viral loads measured in the colonic mucosa of infected patient ranged from 5 to 236961 genome copies by microgram of total extracted DNA. No relationship was observed between the severity of the disease and the viral load level. Furthermore, CMV disappeared in five infected IBD patients in remission without antiviral agents. In conclusion, these results showed infrequent CMV detection in colonic biopsies of IBD patients during exacerbation leaving open the question of the relationship between CMV reactivation and the onset or the severity of IBD exacerbation. |
| | |
Authors:
|
Nicolas Lévêque; Hedia Brixi-Benmansour; Thierry Reig; Fanny Renois; Déborah Talmud; Véronique Brodard; Jean-François Coste; Christophe De Champs; Laurent Andréoletti; Marie-Danièle Diebold |
Related Documents
:
|
16648007 - Retrospective diagnosis of congenital cytomegalovirus infection using umbilical cord. 12212357 - Ileal perforation caused by cytomegalovirus infection in an immunocompetent adult. 1852147 - Prevention and treatment of cytomegalovirus infection. 1973707 - Congenital rubella infection: escape of one monozygotic twin with two amnions, one chor... 23665677 - Theileria induces oxidative stress and hif1α activation that are essential for host le... 8077507 - Tinea capitis: epidemiology, diagnosis, treatment, and control. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of medical virology Volume: 82 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-09 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
|
Languages: eng Pagination: 1694-700 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Wiley-Liss, Inc. |
Affiliation:
|
Medical Virology Unit, University Hospital, Reims, France. nleveque@chu-reims.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biopsy Colon / virology Cytomegalovirus / isolation & purification* Cytomegalovirus Infections / complications*, epidemiology DNA, Viral / genetics, isolation & purification Female Humans Inflammatory Bowel Diseases / etiology*, pathology Intestinal Mucosa / virology Male Middle Aged Polymerase Chain Reaction / methods Prevalence Retrospective Studies Severity of Illness Index Viral Load Virology / methods |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular detection of adeno-associated virus in cases of spontaneous and intentional human abortion...
Next Document: Anchored pan dengue RT-PCR and fast sanger sequencing for detection of dengue RNA in human serum.