Document Detail


Low-frequency EPR detection of chromium(V) formation by chromium(VI) reduction in whole live mice.
MedLine Citation:
PMID:  8080269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurements by direct low frequency EPR spectroscopy provide the first evidence that Cr(V) is generated in one-electron reduction of Cr(VI) in live mice. The Cr(V) yield reached a maximum about 10 min following Cr(VI) intravenous injection and then decayed slowly with a life time of approximately 37 min. The time for the Cr(V) EPR signal to reach maximum intensity increased with the dose of Cr(VI). A discernible EPR signal was still observable at a dose as low as 0.1 mmol/kg. The Cr(V) was found predominantly in the liver, with a small amount in the blood. No Cr(V) signal was detectable in heart, spleen, kidney, and lung. Pretreatment of the animals with metal ion chelators, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, and 1,10-phenanthroline significantly reduced the intensity of the Cr(V) signal that was observed.
Authors:
K J Liu; J Jiang; H M Swartz; X Shi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  313     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-30     Completed Date:  1994-09-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Affiliation:
Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromates / metabolism
Chromium / analysis,  metabolism*
Cross-Linking Reagents
Edetic Acid / pharmacology
Electron Spin Resonance Spectroscopy / methods
Kinetics
Mice
Mice, Inbred BALB C
Oxidation-Reduction
Pentetic Acid / pharmacology
Phenanthrolines / pharmacology
Time Factors
Grant Support
ID/Acronym/Agency:
GM 34250/GM/NIGMS NIH HHS; RR-01811/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Chromates; 0/Cross-Linking Reagents; 0/Phenanthrolines; 10588-01-9/sodium bichromate; 60-00-4/Edetic Acid; 66-71-7/1,10-phenanthroline; 67-43-6/Pentetic Acid; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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