Document Detail


Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy.
MedLine Citation:
PMID:  21046223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles.
METHODS: Follicular fluid was collected from ovarian follicles ≥ 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses.
RESULTS: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p = 0.045).
CONCLUSIONS: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels.
Authors:
Tugba Altun; Sangita Jindal; Keri Greenseid; Jun Shu; Lubna Pal
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Publication Detail:
Type:  Journal Article     Date:  2010-11-03
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  28     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-27     Completed Date:  2011-08-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Affiliation:
Ankara State Research and Training Hospital, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Embryo Transfer
Estradiol / blood
Female
Fertilization in Vitro*
Follicular Fluid / metabolism*
Humans
Interleukin-6 / analysis*
Logistic Models
Multivariate Analysis
Ovarian Follicle
Pregnancy
Retrospective Studies
Chemical
Reg. No./Substance:
0/IL6 protein, human; 0/Interleukin-6; 50-28-2/Estradiol
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