| Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. | |
| | |
MedLine Citation:
|
PMID: 21046223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. METHODS: Follicular fluid was collected from ovarian follicles ≥ 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. RESULTS: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p = 0.045). CONCLUSIONS: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels. |
| | |
Authors:
|
Tugba Altun; Sangita Jindal; Keri Greenseid; Jun Shu; Lubna Pal |
Related Documents
:
|
2237993 - The reliability of menses to indicate the return of ovulation in breastfeeding women in... 10966983 - A rapid decline in serum oestradiol concentrations around the mid-luteal phase had no a... 2889633 - Cesarean section; changing patterns in saudi arabia. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-03 |
Journal Detail:
|
Title: Journal of assisted reproduction and genetics Volume: 28 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-04-27 Completed Date: 2011-08-11 Revised Date: 2012-03-01 |
Medline Journal Info:
|
Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 245-51 Citation Subset: IM |
Affiliation:
|
Ankara State Research and Training Hospital, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cross-Sectional Studies Embryo Transfer Estradiol / blood Female Fertilization in Vitro* Follicular Fluid / metabolism* Humans Interleukin-6 / analysis* Logistic Models Multivariate Analysis Ovarian Follicle Pregnancy Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/IL6 protein, human; 0/Interleukin-6; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Methodological issues in child welfare and children's mental health implementation research.
Next Document: Dynamic as well as stable protein interactions contribute to genome function and maintenance.