| Low-fat dietary pattern and lipoprotein risk factors: the Women's Health Initiative Dietary Modification Trial. | |
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MedLine Citation:
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PMID: 20164311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Women's Health Initiative Dietary Modification Trial tested the effects on chronic disease of a dietary pattern lower in fat and higher in vegetables, fruit, and grains. OBJECTIVE: The objective was to evaluate the effects of dietary carbohydrate changes on lipids and lipoprotein composition. DESIGN: Postmenopausal women were randomly assigned to an intervention or a comparison group for a mean of 8.1 y. Lipoprotein analyses and subclasses were based on subsamples of 2730 and 209 participants, respectively. RESULTS: At year 6, the total reported fat intake was 7.8% lower and carbohydrate intake was 7.6% higher in the intervention group than in the comparison group. Triglyceride change between groups differed by 2.3, 3.8, and -0.8 mg/dL at 1, 3, and 6 y, respectively, and HDL-cholesterol change differed by -1.6, -0.7, and -1.0 mg/dL at 1, 3, and 6 y, respectively. Changes did not differ by age, ethnicity, or obesity. In diabetic intervention women who were white, the triglyceride difference between the intervention and comparison groups was 33.8 mg/dL, whereas in black women with diabetes (n = 50 in the intervention group; n = 83 in the comparison group), the triglyceride difference was 6.4 mg/dL (P for 3-factor interaction = 0.049). No significant changes were observed in apolipoprotein or lipoprotein particles. Reductions in LDL cholesterol varied by quartile of reported lowering of saturated or trans fat. CONCLUSIONS: The replacement of 7-8% of fat intake with complex carbohydrates over 6 y was not associated with clinically adverse effects on triglycerides, HDL cholesterol, or lipoprotein subclasses. Diabetic white women with higher triglyceride concentrations may have greater increases in triglycerides. |
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Authors:
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Barbara V Howard; J David Curb; Charles B Eaton; Charles Kooperberg; Judith Ockene; John B Kostis; Mary Pettinger; Aleksandar Rajkovic; Jennifer G Robinson; Jacques Rossouw; Gloria Sarto; James M Shikany; Linda Van Horn |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-02-17 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-07 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 860-74 Citation Subset: AIM; IM |
Affiliation:
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MedStar Research Institute, Hyattsville, MD 20782, USA. barbara.v.howard@medstar.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Americans Aged Cholesterol, HDL / blood Cholesterol, LDL / blood Diabetes Mellitus / blood*, ethnology Diet, Fat-Restricted* Dietary Carbohydrates / administration & dosage* Dietary Fats / administration & dosage* European Continental Ancestry Group Fatty Acids / administration & dosage Fatty Acids, Unsaturated / administration & dosage Female Food Habits* Humans Lipoproteins / blood* Middle Aged Postmenopause Risk Factors Triglycerides / blood* United States |
| Grant Support | |
ID/Acronym/Agency:
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N01WH22110/WH/WHI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 0/Triglycerides |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2010 Apr;91(4):829-30
[PMID:
20181816
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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