Document Detail

Low extracellular Ca2+ and enzyme release in the perfused rabbit heart.
MedLine Citation:
PMID:  6498626     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that the well-oxygenated perfused rabbit heart releases creatine kinase when treated with the calcium antagonist drug verapamil (VER) in a dose-related manner. It is possible that this effect is related to Ca2+ ion deprivation of the sarcolemma. This possibility was explored by perfusing hearts with low Ca2+ (0.5, 0.23, 0.15, and 0 mM) versus a control group (1.27 mM Ca2+) for 60 min. Low Ca2+ perfusion was associated with reduction in the heart rate--left ventricular systolic pressure product and O2 consumption, tendency for the coronary sinus flow to increase, electromechanical dissociation, prolongation of atrioventricular conduction and QT interval, and decrease in myocardial glycogen. Lower total adenosine nucleotides were found only in the 0 mM Ca2+ group. As the Ca2+ concentration was reduced, the hearts lost increasing amounts of creatine kinase, aspartate aminotransferase, and lactate dehydrogenase. These results confirm the importance of Ca2+ ions in contractile and electrical cardiac functions and show that decreased availability of this cation leads to increasing enzyme leakage resembling that seen in VER-treated hearts.
P A Fortier; G K Bedford; M A Chiong
Related Documents :
8429646 - Effect of calcium and preischemic hypothermia on recovery of myocardial function after ...
11101196 - The cardioprotective effects of a new 1,4-benzothiazepine derivative, jtv519, on ischem...
9390646 - Calcium-activated k+ channels in cerebral arterioles in piglets are resistant to ischemia.
3818956 - Pathophysiology and pathogenesis of stunned myocardium. depressed ca2+ activation of co...
16357946 - Testosterone induced ca2+ influx in bone marrow-derived macrophages via surface binding...
3020026 - Regulation of intracellular ph in human platelets. effects of thrombin, a23187, and ion...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  62     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1985-01-14     Completed Date:  1985-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1158-65     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspartate Aminotransferases / secretion
Calcium / physiology*
Creatine Kinase / secretion
Energy Metabolism
L-Lactate Dehydrogenase / secretion
Myocardial Contraction
Myocardium / metabolism*
Oxygen Consumption
Reg. No./Substance:
7440-70-2/Calcium; EC Dehydrogenase; EC Aminotransferases; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intestinal absorption of free oleic acid in the unanesthetized rat: evidence for a saturable compone...
Next Document:  Effect of glucocorticoids on testosterone production by porcine Leydig cells in primary culture.