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Low expression level of PTEN predicts poor prognosis in chronic lymphocytic leukemia.
MedLine Citation:
PMID:  23013295     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Phosphatase and tension homolog deleted on chromosome ten (PTEN) is one of the best-studied tumor suppressor genes, which can promote cell proliferation and contribute to tumorigenesis. This study aimed to investigate the PTEN mRNA (Pm) expression level in patients with chronic lymphocytic leukemia (CLL) and healthy controls, and its correlation with prognostic factors. Quantitative PCR (qPCR) was used to detect Pm expression. Compared to controls, CLL patients present lower expression level in Pm (p<0.001). In univariate analyses, the expression level of Pm was significantly decreased in patients with Binet C (p<0.001), higher level of β2-microglobulin (β2-MG) (p=0.041), lactate dehydrogenase (LDH) (p=0.019) and ZAP-70 (p=0.008). Higher Pm expression level was found in favorable cytogenetic aberrations (p=0.016) and without p53 aberration groups (p=0.005). Multivariate analysis showed that advanced Binet stage (p=0.027) and p53 aberration (p=0.007) were associated with the low PTEN expression level. Survival analysis showed that low expression of PTEN was associated with shorter time to first treatment (TTFT) (p=0.040). These results show that PTEN might be a new prognostic marker in patients with CLL.
Authors:
Zhi-Jian Zou; Run Zhang; Lei Fan; Li Wang; Cheng Fang; Li-Na Zhang; Shu Yang; Yuan-Yuan Li; Jian-Yong Li; Wei Xu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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