Document Detail


Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer.
MedLine Citation:
PMID:  24532280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNA-126 (miR-126) has been reported to be a tumor suppressor that targets CXCR4 in colorectal cancer (CRC) cells. This study investigated whether miR-126 has any prognostic impact in patients with CRC. MiR-126 and CXCR4 mRNA expression in 92 pairs of CRC and adjacent nontumorous tissues was examined using quantitative real-time PCR, and CXCR4 protein expression was assessed by immunohistochemistry (IHC) and Western blotting. The correlation between miR-126 and CXCR4 protein expression and clinicopathological features and overall survival rate was determined. MiR-126 was downregulated in CRC tissues that expressed high levels of CXCR4 mRNA. IHC and Western blotting detected high expression of CXCR4 protein in CRC tissues. An inverse correlation was observed between miR-126 and CXCR4 protein expression in CRC tissues. Moreover, low miR-126 and high CXCR4 protein expression was associated with distant metastasis, clinical TNM stage, and poor survival. Multivariate analysis indicated that miR-126 was an independent prognostic factor for overall survival, suggesting its clinical significance as a prognostic predictor in CRC patients.
Authors:
Yaling Liu; Yu Zhou; Xiao Feng; Pengchun Yang; Jingfang Yang; Ping An; Hao Wang; Shicai Ye; Caiyuan Yu; Yanting He; Hesheng Luo
Publication Detail:
Type:  Journal Article     Date:  2014-01-29
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  53     ISSN:  1098-2264     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-02-17     Completed Date:  2014-08-19     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Colorectal Neoplasms / diagnosis,  genetics*,  metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Male
MicroRNAs / genetics*,  metabolism
Middle Aged
Neoplasm Staging
Prognosis
Receptors, CXCR4 / genetics,  metabolism
Tumor Markers, Biological / genetics*,  metabolism
Chemical
Reg. No./Substance:
0/CXCR4 protein, human; 0/MIRN126 microRNA, human; 0/MicroRNAs; 0/Receptors, CXCR4; 0/Tumor Markers, Biological
Comments/Corrections
Comment In:
Genes Chromosomes Cancer. 2014 Oct;53(10):882   [PMID:  24916021 ]
Genes Chromosomes Cancer. 2014 Oct;53(10):881   [PMID:  24898922 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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