| Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer. | |
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MedLine Citation:
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PMID: 22240664 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent studies have suggested that dysregulation of autophagy plays a pivotal role in tumorigenesis. Here, we determined the prognostic value of autophagy-related protein Beclin 1 in gastric cancer. A total of 153 primary gastric cancer patients were subjected to analysis of Beclin 1 expression and survival prognosis. Among them, 68 patients were assigned randomly and used as a training set to generate a cutoff score for Beclin 1 expression by receive operating characteristic (ROC) curve analysis. The ROC-generated cutoff score was subjected to analyze the association of Beclin 1 with clinical characteristics and patient outcome. In a testing set (n = 85) and overall patients (n = 153), both univariate and multivariate analysis found that low expression of Beclin 1 predicted adverse overall survival and progression-free survival for gastric cancer patients. Furthermore, in each stage of gastric cancer patients, Beclin 1 expression was a prognostic indicator in patients with stage II, III and IV. Importantly, a reverse relationship between Beclin 1 and Bcl-xL expression was demonstrated. In patients of elevated Bcl-xL expression, a subset with lower Beclin 1 expression displayed an inferior overall survival and progression-free survival than those with higher Beclin 1 expression. Thus, our data demonstrated that low expression of Beclin 1, associated with high Bcl-xL, played as an independent biomarker, contributing to a more aggressive cancer cell phenotype and poor prognosis for gastric tumor. |
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Authors:
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Wei-Hua Zhou; Fang Tang; Jie Xu; Xing Wu; Shaobing Yang; Zhiying Feng; Yungang Ding; Xiang-Bo Wan; Zhong Guan; Haigang Li; Dongjun Lin; Chunkui Shao; Quentin Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-01 |
Journal Detail:
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Title: Autophagy Volume: 8 ISSN: 1554-8635 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Hematology; the Third Affiliated Hospital; Sun Yat-sen University; Guangzhou, China; State Key Laboratory of Oncology in South China; Cancer Center; Sun Yat-sen University; Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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