| Low doses of urban air particles from Buenos Aires promote oxidative stress and apoptosis in mice lungs. | |
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MedLine Citation:
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PMID: 21047167 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: We studied lung responses to low doses of UAP-BA (15 µg), with special emphasis on oxidative balance. METHODS: We assessed cell viability, total cell number (TCN) and cell differential (CD) on bronchoalveolar lavages (BAL), oxidative metabolism in lung homogenates by tertbutylhydroperoxide-initiated chemiluminescence (CL), thiobarbituric reactive substances (TBARS), total reactive antioxidant potential (TRAP), reduced glutathione (GSH), and apoptosis in lung sections. RESULTS: We found that low UAP-BA exposure increases TCN, modifies CD, and decreases cell viability in the BAL. In lung homogenates, TBARS and CL rose while TRAP and GSH showed no alteration when compared to controls. Occurrence of apoptosis evaluated by TUNEL assay was markedly augmented in UAP-BA exposed animals. CONCLUSIONS: Our data further implicate oxidative stress as a possible inducer of apoptosis in lungs from animals exposed to low concentrations of this urban environmental contaminant. |
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Authors:
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Susana Martin; Eugenio Fernandez-Alanis; Veronica Delfosse; Pablo Evelson; Juan S Yakisich; Paulo H Saldiva; Deborah R Tasat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-03 |
Journal Detail:
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Title: Inhalation toxicology Volume: 22 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1064-71 Citation Subset: IM |
Affiliation:
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School of Science and Technology, National University of San Martín, San Martín, Buenos Aires, Argentina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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