Document Detail


Low doses of nicotine-induced fetal cardiovascular responses, hypoxia, and brain cellular activation in ovine fetuses.
MedLine Citation:
PMID:  19459226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal exposure to nicotine is associated with a variety of adverse outcomes. The present study investigated the effect of low doses of nicotine during pregnancy on fetal blood gases, cardiovascular system, and cellular activation in the brain. Intravenous administration of nicotine 10 or 25 microg/kg into ewe did not affect maternal blood gases, blood pressure, and heart rate. Maternal administration of nicotine also had no effect on fetal blood electrolyte concentrations, osmolality levels, and lactic acid levels. However, it significantly reduced fetal blood pO2 levels and oxygen saturation, increased fetal arterial blood pressure and decreased heart rate in utero. In addition, exposure to low doses of nicotine increased the expression of Fos in the paraventricular nucleus (PVN) and subfornic organ (SFO) in the fetal brain. The data demonstrated that even low doses of nicotine could impact significantly on fetal cardiovascular and central nervous systems, as well as oxygen status, and suggested a toxic risk to fetuses of exposure to low levels nicotine or second-hand smoking during pregnancy.
Authors:
Junchang Guan; Caiping Mao; Feicao Xu; Liyan Zhu; Yujuan Liu; Chongsong Geng; Lubo Zhang; Zhice Xu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicology     Volume:  30     ISSN:  1872-9711     ISO Abbreviation:  Neurotoxicology     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2010-03-01     Revised Date:  2010-12-03    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  290-7     Citation Subset:  IM    
Affiliation:
Perinatal Biology Center, Soochow University School of Medicine, Suzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology*,  drug effects*,  embryology
Cardiovascular System / drug effects,  embryology
Female
Fetal Blood / drug effects,  metabolism
Fetal Hypoxia / chemically induced*,  embryology,  metabolism
Fetus / drug effects,  embryology,  metabolism
Heart Rate, Fetal / drug effects*,  physiology
Maternal-Fetal Exchange / drug effects,  physiology
Nicotine / administration & dosage*,  toxicity
Pregnancy
Sheep / embryology,  metabolism
Grant Support
ID/Acronym/Agency:
R01 HL082779-04/HL/NHLBI NIH HHS; R01 HL083966-03/HL/NHLBI NIH HHS; R01 HL089012-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
54-11-5/Nicotine
Comments/Corrections

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