| Low doses of endothelin-1 inhibit atrial natriuretic peptide secretion. | |
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MedLine Citation:
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PMID: 8477643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the interaction between endothelin-1 (ET-1) and atrial natriuretic peptide (ANP), the effects of ET-1 on ANP secretion were investigated in isolated perfused rat hearts and in conscious unrestrained rats. Perfusion with 10(-9) M ET-1 stimulated ANP secretion from the isolated perfused rat heart. However, 10(-10) M ET-1 significantly decreased ANP secretion for the initial 15 min of the perfusion period. The perfusion with 10(-11) M ET-1, which is near the plasma level of ET-1 (2 x 10(-12) M), inhibited ANP secretion throughout the perfusion period. The perfusion of 10(-12) M ET-1 slightly decreased ANP secretion. After the ET-1 perfusion period, ANP secretion increased in proportion to ET-1 dose. The inhibitory action of ET-1 on ANP secretion was almost abolished by simultaneous perfusion of indomethacin, a cyclooxygenase inhibitor, but not by methylene blue, an inhibitor of soluble guanylate cyclase. In conscious unrestrained rats the iv infusion of 1 pmol/kg.min ET-1, which doubled the plasma ET-1 level, slightly but significantly decreased the plasma ANP level 5 and 10 min after the initiation of the infusion. The infusion of 10 and 30 pmol/kg.min ET-1 increased the plasma ANP level. These results demonstrate that low doses of ET-1 exert an inhibitory and short-acting action on ANP secretion from the heart, although high doses of ET-1 exert stimulating and long-lasting action, and suggest that prostanoids are involved in this inhibitory action. |
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Authors:
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G Shirakami; K Nakao; Y Saito; T Magaribuchi; M Mukoyama; H Arai; K Hosoda; S Suga; K Mori; H Imura |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Endocrinology Volume: 132 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-05-25 Completed Date: 1993-05-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1905-12 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Kyoto University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / secretion* Blood Pressure / drug effects Dose-Response Relationship, Drug Endothelins / administration & dosage, pharmacology* Heart / drug effects, physiology Heart Rate / drug effects Indomethacin / pharmacology Kinetics Male Methylene Blue / pharmacology Perfusion Pressure Rats Rats, Inbred WKY |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 53-86-1/Indomethacin; 61-73-4/Methylene Blue; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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