Document Detail

Low dose weekly methotrexate in early pregnancy. A case series and review of the literature.
MedLine Citation:
PMID:  10955326     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the teratogenic risk of low dose weekly pulses of methotrexate (MTX) inadvertently taken during the first trimester of pregnancy. METHODS: We assessed pregnancy and neonatal outcome of 4 patients with rheumatic disease treated with weekly pulses of 5 to 15 mg of MTX for a mean duration of 4 years. RESULTS: The 4 patients had continued MTX treatment from one to 6 weeks of gestation. One patient miscarried at Week 6, the other pregnancies ended with the delivery of healthy children. Chromosome analysis of one child was normal. CONCLUSION: In spite of the absence of congenital anomalies in our cases, safe contraception in fertile patients who start low dose weekly MTX is mandatory.
M Ostensen; H Hartmann; K Salvesen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  27     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-27     Completed Date:  2000-12-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1872-5     Citation Subset:  IM    
Center for Mothers with Rheumatic Disease, Department of Rheumatology, University Hospital of Trondheim, Norway.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Abortion, Spontaneous / chemically induced
Antirheumatic Agents / administration & dosage*,  adverse effects
Arthritis, Rheumatoid / drug therapy*
Dose-Response Relationship, Drug
Folic Acid Antagonists / adverse effects*
Gestational Age
Maternal-Fetal Exchange
Methotrexate / administration & dosage*,  adverse effects
Pregnancy Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 0/Folic Acid Antagonists; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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