Document Detail

Low-dose vincristine-associated bilateral vocal cord paralysis.
MedLine Citation:
PMID:  10578547     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vincristine-associated peripheral neuropathy is a well-described entity. We describe a case of vincristine-induced vocal cord paralysis, which is a rare complication of this drug. We report herein the second case of bilateral vocal cord paralysis in a patient receiving conventional doses of vincristine. OBJECTIVE: To present a case report of vincristine-associated vocal cord paralysis and to review the relevant English language literature on this subject. DESIGN: Report and review of the literature. SETTING: Outpatient community cancer center. PATIENT: A 58-year-old female with a diffuse large cell lymphoma stage IV receiving cyclophosphamide, doxorubicin, vincristine, and prednisone. RESULTS: Bilateral vocal cord paralysis occurred in this patient receiving vincristine as part of her chemotherapy regimen. In addition to this case there have been a total of 25 prior reports, which are reviewed in the text. CONCLUSION: The incidence of bilateral vocal cord paralysis in patients receiving vincristine on the usual low-dose schedule is low. Prompt withdrawal of the offending agent results in prompt recovery without untoward long-lasting sequela.
S P Ryan; S A DelPrete; P W Weinstein; R B Erichson; M H Bar; K M Lo; N S Cohen; I Tepler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Connecticut medicine     Volume:  63     ISSN:  0010-6178     ISO Abbreviation:  Conn Med     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-03     Completed Date:  2000-01-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372745     Medline TA:  Conn Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  583-4     Citation Subset:  IM    
Carl and Dorothy Bennett Cancer Center, Stamford Hospital, USA.
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MeSH Terms
Antineoplastic Agents, Phytogenic / adverse effects*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Lymphoma, Large B-Cell, Diffuse / drug therapy
Middle Aged
Vincristine / adverse effects*
Vocal Cord Paralysis / chemically induced*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 57-22-7/Vincristine

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