| Low-dose vincristine-associated bilateral vocal cord paralysis. | |
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MedLine Citation:
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PMID: 10578547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vincristine-associated peripheral neuropathy is a well-described entity. We describe a case of vincristine-induced vocal cord paralysis, which is a rare complication of this drug. We report herein the second case of bilateral vocal cord paralysis in a patient receiving conventional doses of vincristine. OBJECTIVE: To present a case report of vincristine-associated vocal cord paralysis and to review the relevant English language literature on this subject. DESIGN: Report and review of the literature. SETTING: Outpatient community cancer center. PATIENT: A 58-year-old female with a diffuse large cell lymphoma stage IV receiving cyclophosphamide, doxorubicin, vincristine, and prednisone. RESULTS: Bilateral vocal cord paralysis occurred in this patient receiving vincristine as part of her chemotherapy regimen. In addition to this case there have been a total of 25 prior reports, which are reviewed in the text. CONCLUSION: The incidence of bilateral vocal cord paralysis in patients receiving vincristine on the usual low-dose schedule is low. Prompt withdrawal of the offending agent results in prompt recovery without untoward long-lasting sequela. |
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Authors:
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S P Ryan; S A DelPrete; P W Weinstein; R B Erichson; M H Bar; K M Lo; N S Cohen; I Tepler |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Connecticut medicine Volume: 63 ISSN: 0010-6178 ISO Abbreviation: Conn Med Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-01-03 Completed Date: 2000-01-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372745 Medline TA: Conn Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 583-4 Citation Subset: IM |
Affiliation:
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Carl and Dorothy Bennett Cancer Center, Stamford Hospital, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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adverse effects* Antineoplastic Combined Chemotherapy Protocols / therapeutic use Female Humans Lymphoma, Large B-Cell, Diffuse / drug therapy Middle Aged Vincristine / adverse effects* Vocal Cord Paralysis / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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