| Low-dose, time-resolved, contrast-enhanced 3D MR angiography in cardiac and vascular diseases: correlation to high spatial resolution 3D contrast-enhanced MRA. | |
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MedLine Citation:
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PMID: 18555032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the effectiveness of low-dose, contrast-enhanced, time-resolved, three-dimensional (3D) magnetic resonance (MR) angiography (TR-MRA) in the assessment of various cardiac and vascular diseases, and to compare the results with high-resolution contrast-enhanced MRA (CE-MRA). MATERIALS AND METHODS: Thirty consecutive patients underwent contrast-enhanced 3D TR-MRA and high spatial resolution 3D CE-MRA for evaluation of cardiac and thoracic vascular diseases at 1.5 T, and neurovascular, abdominal and peripheral vascular diseases at 3T. Gadolinium-based contrast medium was administered at a constant dose of 5 ml for TR-MRA, and 20 ml (lower extremity 30 ml) for CE-MRA. Two readers evaluated image quality using a four-point scale (from 0=excellent to 3=non-diagnostic), artefacts and findings on both datasets. Interobserver variability was tested with kappa coefficient. RESULTS: The overall image quality for TR-MRA was in the diagnostic range (median 0, range 0-1; k=0.74). Readers demonstrated important additional dynamic information on TR-MRA in 28 of 30 patients (k=0.84). Confident evaluation of organ perfusion (n=23), arteriovenous malformation/fistula flow patterns (n=7), exclusion of intra-cardiac shunts (n=6), and assessment of stent and conduit patency (n=5) were performed by both readers using TR-MRA. Readers demonstrated fine vascular details with higher confidence in 10 patients on CE-MRA. Using CE-MRA, Reader 1 and 2 depicted anatomical details in 6 and 5 patients, respectively, only on CE-MRA. CONCLUSION: Low-dose TR-MRA yields rapid and important functional and anatomical information in patients with cardiac and vascular diseases. Due to limited spatial resolution, TR-MRA is inferior to CE-MRA in demonstrating fine vascular details. |
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Authors:
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M S Krishnam; A Tomasian; D G Lohan; L Tran; J P Finn; S G Ruehm |
Publication Detail:
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Type: Journal Article Date: 2008-03-28 |
Journal Detail:
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Title: Clinical radiology Volume: 63 ISSN: 0009-9260 ISO Abbreviation: Clin Radiol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-16 Completed Date: 2008-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 744-55 Citation Subset: IM |
Affiliation:
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Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, CA 90095-7206, USA. mkrishnam@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Contrast Media / administration & dosage* Female Gadolinium DTPA / administration & dosage*, diagnostic use Heart Diseases / diagnosis* Humans Image Enhancement / methods Imaging, Three-Dimensional / methods* Magnetic Resonance Angiography / methods* Male Middle Aged Vascular Diseases / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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