Document Detail


Low-dose subcutaneous erythropoietin in continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  2024637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated changes in hematocrit in patients on continuous ambulatory peritoneal dialysis (CAPD) before and after the administration of erythropoietin (EPO). Thirty-five patients were evaluated at the beginning of treatment with CAPD and after an average of 3.5 years on CAPD; mean hematocrit (Hct) rose from 25.4 +/- 5.4% to 28.1 +/- 6.7% (P less than 0.001). In the period before EPO administration 11 patients required a total of 44 transfusions (one patient needed 23 transfusions). Fifteen patients were started on subcutaneous erythropoietin 3,000 units 3 times a week and were followed for a mean period of 6.3 months. Hct rose from 23.8 +/- 1.8% to 25.2 +/- 2.4% (P less than 0.01) within the first 2 weeks and up to 27.5 +/- 3.7% (P less than 0.01) in the fourth week. By the eighth week the target Hct (30 to 35%) was reached. During the next 5 months the EPO doses were adjusted to each patient's needs ranging between 2,000 U per week to 4,000 U 3 times per week. Mild hypertension was the only side effect seen in some of the patients. In conclusion low dose subcutaneous EPO is effective in managing the anemia of patients on CAPD with only minor side effects.
Authors:
C Rotellar; M J Mazzoni; W F Mosher; M Aminrazavi; A Bauer; T A Rakowski; G E Schreiner; J F Winchester
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  37     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-05     Completed Date:  1991-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-3     Citation Subset:  IM    
Affiliation:
Georgetown University Medical Center, Washington, DC 20007.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia / drug therapy
Creatine / blood
Dose-Response Relationship, Drug
Erythropoietin / administration & dosage*,  therapeutic use
Female
Hematocrit
Humans
Injections, Subcutaneous
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Phosphates / blood
Potassium / blood
Chemical
Reg. No./Substance:
0/Phosphates; 11096-26-7/Erythropoietin; 57-00-1/Creatine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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