Document Detail


Low-dose and short-term cyclosporine treatment in patients with chronic idiopathic urticaria: a clinical and immunological evaluation.
MedLine Citation:
PMID:  18477227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study aimed to evaluate the effectiveness of 2.5 mg/kg/day cyclosporin (CsA) treatment in patients with severe chronic idiopathic urticaria (CIU) and the impact of CsA treatment on several cytokines involved in the etiopathogenesis of CIU. Twenty-seven CIU patients and 24 healthy control subjects were included in the study. The autologous serum skin test (ASST) for autoantibodies and urticaria activity scoring (UAS) were measured for the evaluation of the clinical severity and the response to therapy, and the serum levels of interleukin (IL)-6, IL-8, IL-2 receptor, IL-1beta, tumor necrosis factor (TNF)-alpha and IL-5 were measured. The mean UAS score was 32.07 +/- 7.05 and 6.22 +/- 3.84 before and after CsA treatment, respectively. The serum IL-2 receptor, TNF-alpha and IL-5 levels of patients before CsA treatment were statistically higher than those of the control group (P = 0.001), and after 4 weeks of CsA therapy the mean IL-2R, TNF-alpha and IL-5 levels were significantly decreased. The data from this study demonstrate that CsA therapy is efficient and safe for CIU patients. Increase in clinical efficacy and marked decreases in serum cytokine levels suggest that inhibition of cytokine generation is involved in the action of the drug in this clinical setting.
Authors:
H Serhat Inaloz; Savas Ozturk; Cenk Akcali; Necmettin Kirtak; Mehmet Tarakcioglu
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  35     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  276-82     Citation Subset:  IM    
Affiliation:
Department of Dermatology, School of Medicine, Gaziantep University, Gaziantep, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chronic Disease
Cyclosporine / administration & dosage,  therapeutic use*
Cytokines / blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunosuppressive Agents / administration & dosage,  therapeutic use*
Male
Prospective Studies
Treatment Outcome
Urticaria / drug therapy*,  immunology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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