| Low dose recombinant interferon alfa treatment for classic Kaposi's sarcoma. | |
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MedLine Citation:
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PMID: 8215494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: High doses of interferon alfa are used to treat Kaposi's sarcoma in patients with immunodeficiency, whereas low doses are generally ineffective. Following low-dose recombinant interferon alfa treatment for lymphoma, two patients showed a regression of their hematologic malignancy-associated Kaposi's sarcoma. This observation prompted us also to try low-dose interferon alfa treatment in uncomplicated classic Kaposi's sarcoma, and two additional patients were thus treated on an outpatient basis. OBSERVATIONS: Initial response was noted after 3 to 13 weeks of treatment. Remission was achieved after 4 to 6 months of low-dose interferon alfa treatment and its duration was 8 to 14 months. Recurrences were treated again and additional remissions were obtained after only 5 to 8 weeks of treatment. CONCLUSION: Low-dose interferon alfa treatment may represent an effective therapeutic modality for the treatment of patients with both lymphoma-associated and uncomplicated classic Kaposi's sarcoma. |
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Authors:
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E Tur; S Brenner; R Michalevicz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 129 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-02 Completed Date: 1993-11-02 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1297-300 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Interferon Type I, Recombinant / administration & dosage* Male Middle Aged Sarcoma, Kaposi / therapy* Skin Neoplasms / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I, Recombinant |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 1994 Jun;130(6):799-801
[PMID:
8043141
]
Arch Dermatol. 1993 Oct;129(10):1320-3 [PMID: 8215499 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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