Document Detail

Low-dose radiotherapy in 179 patients with Peyronie's disease: treatment outcome and current sexual functioning.
MedLine Citation:
PMID:  10889390     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To analyse retrospectively treatment outcome in patients irradiated for Peyronie's disease. METHODS AND MATERIALS: The records of 179 patients, median age 52 years, that received radiotherapy (RT) between 1982 and 1997 were reviewed. 78% presented with painful erections and 89% with penile deformity. The symptoms were present for a median duration of 6 months (range, 1-72 months). The RT schedule consisted of 13.5 Gy (9 x 1.5 Gy, 3 fractions per week) using orthovoltage X-rays in 123 patients or 12 Gy (6 x 2 Gy, daily fractions) using electrons in 56 patients. A questionnaire regarding current sexual functioning was mailed to 130 patients whose addresses could be traced; 106 (82%) responded. RESULTS: At mean follow-up period of 3 months, 83% reported that pain was diminished or had disappeared after RT. Twenty-three percent of patients reported a decrease in penile deformity. Following RT, surgical correction of penile curvature was performed in 29% of patients. No RT-related complications occurred except transient dysuria in 1 patient. Questionnaire data: 72% of patients were currently sexually active, 48% had erectile dysfunction, and 49% expressed dissatisfaction with their current sexual functioning. CONCLUSION: Low-dose external RT (12-13.5 Gy) results in relief of pain in the majority of patients with Peyronie's disease. Improvement in penile deformity was observed, avoiding surgery in a number of patients. No significant RT-associated morbidity was encountered. It is disappointing that almost 50% of patients complain of sexual functioning, but this is presumably not related to radiotherapy.
L Incrocci; A Wijnmaalen; A K Slob; W C Hop; P C Levendag
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  47     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-04     Completed Date:  2000-08-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1353-6     Citation Subset:  IM    
Department of Radiation Oncology, Daniel den Hoed Cancer Centre and Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Dose Fractionation
Follow-Up Studies
Middle Aged
Pain / radiotherapy
Penile Erection*
Penile Induration / radiotherapy*
Penis / abnormalities,  surgery
Radiotherapy Dosage
Retrospective Studies
Treatment Outcome

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