| Low-dose oral contraceptives and 24-hour ambulatory blood pressure. | |
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MedLine Citation:
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PMID: 9486514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate in normotensive women the influence of low-dose oral contraceptives (OC, monophasic formulations containing 30 microg of estrogen) on 24-h blood pressure. METHODS: We evaluated prospectively in 15 normotensive healthy women (three smokers) the influence of OC on 24-h ambulatory blood pressure monitoring (ABPM). ABPM was performed (SpaceLabs 90207) before and after 6-9 months of use of OC. We also evaluated ABPM in eight women (two smokers) before and after 6-8 months on an intrauterine device (IUD) as contraceptive method--these were used as control subjects. RESULTS: OC produced a significant increase in 24-h ABPM values (from 120+/-3/75+/-2 to 128+/-4/81+/-2 mmHg, P < 0.04) which was particularly evident for night-time values (from 108+/-2/64+/-2 to 120+/-4/73+/-2 mmHg, P < 0.02). After OC, two normotensive women developed 'hypertensive values'. In OC users there was a slight but significant increase in body weight which did not correlate with the increase of blood pressure. In contrast, in the control group (IUD) neither ABPM values nor weight were modified by the contraceptive maneuver. CONCLUSIONS: In normotensive women, low-dose OC may increase blood pressure to an extent that, at least in some women, may affect blood pressure control towards 'hypertensive values'. This stresses the importance of monitoring blood pressure values during OC treatment. |
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Authors:
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F Cardoso; J Polónia; A Santos; J Silva-Carvalho; J Ferreira-de-Almeida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 59 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-03-31 Completed Date: 1998-03-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: IRELAND |
Other Details:
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Languages: eng Pagination: 237-43 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Faculty of Medicine of Porto, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects* Blood Pressure Monitoring, Ambulatory Case-Control Studies Contraceptives, Oral, Combined / adverse effects, pharmacology* Female Humans Hypertension / chemically induced Intrauterine Devices Prospective Studies Risk Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Combined |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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