Document Detail

Low-dose oral contraceptives and 24-hour ambulatory blood pressure.
MedLine Citation:
PMID:  9486514     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate in normotensive women the influence of low-dose oral contraceptives (OC, monophasic formulations containing 30 microg of estrogen) on 24-h blood pressure. METHODS: We evaluated prospectively in 15 normotensive healthy women (three smokers) the influence of OC on 24-h ambulatory blood pressure monitoring (ABPM). ABPM was performed (SpaceLabs 90207) before and after 6-9 months of use of OC. We also evaluated ABPM in eight women (two smokers) before and after 6-8 months on an intrauterine device (IUD) as contraceptive method--these were used as control subjects. RESULTS: OC produced a significant increase in 24-h ABPM values (from 120+/-3/75+/-2 to 128+/-4/81+/-2 mmHg, P < 0.04) which was particularly evident for night-time values (from 108+/-2/64+/-2 to 120+/-4/73+/-2 mmHg, P < 0.02). After OC, two normotensive women developed 'hypertensive values'. In OC users there was a slight but significant increase in body weight which did not correlate with the increase of blood pressure. In contrast, in the control group (IUD) neither ABPM values nor weight were modified by the contraceptive maneuver. CONCLUSIONS: In normotensive women, low-dose OC may increase blood pressure to an extent that, at least in some women, may affect blood pressure control towards 'hypertensive values'. This stresses the importance of monitoring blood pressure values during OC treatment.
F Cardoso; J Polónia; A Santos; J Silva-Carvalho; J Ferreira-de-Almeida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  59     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-31     Completed Date:  1998-03-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine of Porto, Portugal.
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MeSH Terms
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Case-Control Studies
Contraceptives, Oral, Combined / adverse effects,  pharmacology*
Hypertension / chemically induced
Intrauterine Devices
Prospective Studies
Risk Factors
Time Factors
Reg. No./Substance:
0/Contraceptives, Oral, Combined

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