| Low-dose nesiritide improves renal function in heart failure patients following acute myocardial infarction. | |
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MedLine Citation:
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PMID: 20339970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to investigate the effect of low-dose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction. Sixty patients were randomized into nesiritide (loading dose 0.5 microg/kg, maintenance dose 0.0075 microg/kg/min) and nitroprusside groups. Compared with the nitroprusside group, the nesiritide group had a greater heart rate reduction (P < 0.05), higher 24 h urine volume (P < 0.001), and more significant alleviation in dyspnea (P < 0.001). The prevalence of hypotension in the nesiritide group was lower than in the nitroprusside group (7.4% vs 28.5%, P < 0.05). The nesiritide group had a greater reduction in serum noradrenaline, angiotensin II, aldosterone, endothelin, and N-terminal prohormone brain natriuretic peptide (all P < 0.01). The mean serum creatinine in the nesiritide group was reduced (109.4 +/- 26.6 vs 102.8 +/- 21.6 micromol/l, P < 0.01), whereas it remained unchanged in the nitroprusside group (106.8 +/- 20 vs 106.0 +/- 19.2 micromol/l, P > 0.05). The rehospitalization or mortality rate was similar between the two groups 3 months after the therapy (P > 0.05). We conclude that low-dose nesiritide is more effective in suppressing the activation of the sympathetic and renin-angiotensin systems. It also improves the clinical symptoms and enhances renal function, but its effect on hospital readmission or mortality rate needs further investigation. |
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Authors:
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Qiang Zhao; Tong-Guo Wu; Yi Lin; Biao Li; Jing-Yun Luo; Le-Xin Wang |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-03-26 |
Journal Detail:
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Title: Heart and vessels Volume: 25 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 97-103 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Red Cross Hospital of Guangzhou City, 510220, Guangzhou, Guangdong Province, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cardiovascular Agents / administration & dosage*, adverse effects Chi-Square Distribution Creatinine / blood Female Heart Failure / drug therapy*, etiology, mortality, physiopathology Hemodynamics / drug effects Humans Kidney / drug effects*, physiopathology Kidney Diseases / drug therapy*, etiology, mortality, physiopathology Male Middle Aged Myocardial Infarction / complications, drug therapy*, mortality, physiopathology Natriuretic Peptide, Brain / administration & dosage*, adverse effects, blood Nitroprusside / administration & dosage*, adverse effects Patient Readmission Peptide Fragments / blood Stroke Volume / drug effects Time Factors Treatment Outcome Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cardiovascular Agents; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 15078-28-1/Nitroprusside; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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