Document Detail


Low-dose naltrexone for disease prevention and quality of life.
MedLine Citation:
PMID:  19041189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of low-dose naltrexone (LDN) for the treatment and prophylaxis of various bodily disorders is discussed. Accumulating evidence suggests that LDN can promote health supporting immune-modulation which may reduce various oncogenic and inflammatory autoimmune processes. Since LDN can upregulate endogenous opioid activity, it may also have a role in promoting stress resilience, exercise, social bonding, and emotional well-being, as well as amelioration of psychiatric problems such a autism and depression. It is proposed that LDN can be used effectively as a buffer for a large variety of bodily and mental ailments through its ability to beneficially modulate both the immune system and the brain neurochemistries that regulate positive affect.
Authors:
Norman Brown; Jaak Panksepp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-28
Journal Detail:
Title:  Medical hypotheses     Volume:  72     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  IM    
Affiliation:
Department of Humanities and Social Sciences, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, United States. NPHbrown@aol.com
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MeSH Terms
Descriptor/Qualifier:
Cytokines / immunology*
Dose-Response Relationship, Drug
Humans
Inflammation / immunology*,  prevention & control*
Models, Immunological
Naltrexone / administration & dosage*
Narcotic Antagonists / administration & dosage
Neoplasms / immunology*,  prevention & control*
Quality of Life*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Narcotic Antagonists; 16590-41-3/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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