Document Detail

Low-dose mifepristone for contraception: a weekly versus planned postcoital randomized pilot study.
MedLine Citation:
PMID:  15208051     Owner:  NLM     Status:  MEDLINE    
In this randomized pilot study, we compared the contraceptive efficacy, safety and side effect profiles of weekly versus planned postcoital regimens of low-dose mifepristone. Forty participants were randomized to receive mifepristone 10 mg weekly or planned postcoitally (to be used no more frequently than once every 5 days), for 12 consecutive months. Participants were evaluated monthly to determine pregnancy, ovulation status and acceptability of physical side effects. We ended this pilot study prematurely due to low efficacy and predetermined stopping rules. Three pregnancies during 56 woman-months occurred in the weekly group and three pregnancies during 68 woman-months occurred in the planned postcoital group. Almost half of the participants ovulated monthly on either regimen. The majority of the participants found the physical side effects of these regimens acceptable. Participants in the planned postcoital group, however, found adhering to the regimen more difficult than those in the weekly group. Mifepristone 10 mg used weekly or planned postcoitally did not adequately prevent pregnancy in our pilot study population. Although the concept of intermittent low-dose mifepristone is appealing, the contraceptive effectiveness was disappointing.
Emily M Godfrey; Jacinda T Mawson; Nancy L Stanwood; Stephen L Fielding; Eric A Schaff
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contraception     Volume:  70     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-21     Completed Date:  2005-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Department of Family Medicine, John H. Stroger Hospital of Cook County, 1900 W. Polk Street, Room 1352, Chicago, IL, USA.
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MeSH Terms
Contraceptives, Postcoital, Synthetic / administration & dosage*,  standards
Drug Administration Schedule
Menstruation / drug effects
Mifepristone / administration & dosage*,  standards
Ovulation / blood,  drug effects
Pilot Projects
Pregnancy, Unwanted*
Progesterone / blood
Treatment Failure
Reg. No./Substance:
0/Contraceptives, Postcoital, Synthetic; 57-83-0/Progesterone; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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