| Low dose intravaginal misoprostol versus intracervical baloon catheter for pre-induction cervical ripening. | |
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MedLine Citation:
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PMID: 16167722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The efficacy and safety of low dose misoprostol as a ripening agent compared to the widely used balloon catheter in developing countries is undetermined. OBJECTIVE: To compare the safety and efficacy of a low dose intravaginal misoprostol and intracervical Foley's catheter for cervical ripening. DESIGN: A prospective randomized controlled trial. SETTING: Zonal General Hospital, Kwale, Nigeria from June 1, 1998 to May 30, 2001. METHODS: Candidates for pre-induction cervical ripening were randomized to receive either 250 mcg of intravaginal misoprostol every four hours (n = 60) or intracervical Foley's catheter (n = 61). MAIN OUTCOME MEASURES: Failure to achieve cervical ripening within 24 hours, need for augmentation, maternal and foetal complications. RESULTS: Failure to achieve cervical ripening within two hours was reduced with misoprostol (Relative Risk [RR] 0.63, 95% Confidence Interval [CI] 0.43 - 0.92). Need for oxytocin augmentation was less in the misoprostol group (RR 0.76, 95% CI 0.64 to 0.91). No significant differences existed in rates for uterine hyperstimulation, Caesarean section, maternal and neonatal morbidity. CONCLUSION: Intravaginal misoprostol in a low dose was compared to intracervical balloon catheter for pre-induction ripening of the cervix. |
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Authors:
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T O Tabowei; V O Oboro |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: East African medical journal Volume: 80 ISSN: 0012-835X ISO Abbreviation: East Afr Med J Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2005-09-19 Completed Date: 2005-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372766 Medline TA: East Afr Med J Country: Kenya |
Other Details:
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Languages: eng Pagination: 91-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Zonal General Hospital, Kwale, Delta State, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Adult Balloon Dilatation / adverse effects, methods* Cervical Ripening / drug effects* Dose-Response Relationship, Drug Female Humans Labor, Induced / methods* Misoprostol / administration & dosage*, adverse effects Obstetric Labor Complications / etiology Oxytocics / administration & dosage*, adverse effects Pregnancy Pregnancy Outcome Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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