Document Detail

Low-dose human chorionic gonadotropin during the proliferative phase may adversely affect endometrial receptivity in oocyte recipients.
MedLine Citation:
PMID:  19165663     Owner:  NLM     Status:  MEDLINE    
The effect of low-dose human chorionic gonadotropin (hCG) administration in the proliferative phase of oocyte recipients was investigated in a prospective randomized trial. Sibling oocytes from the same donor were shared at random among two different recipients. In group I oocyte recipients received 750 IU of hCG every three days concomitant to endometrial preparation with estradiol until hCG injection to the donor, whereas in group II recipients received no hCG during endometrial priming with estradiol. Endometrial thickness was significantly lower in group I compared with group II, although similar endometrial thickness was detected during the mock cycle. Pregnancy rates were significantly lower in group I than in group II (13.6% vs. 45.4%, p<0.05). Implantation rates were also significantly lower in group I (1.7% vs. 22.4%, p<0.01). The study was discontinued prematurely for ethical reasons when 22 cycles were completed, as pregnancy rates were very low in group I. In conclusion, hCG administration in the proliferative phase might directly affect endometrial proliferation and receptivity.
Nikos Prapas; Asimina Tavaniotou; Yannis Panagiotidis; Stella Prapa; Evangelia Kasapi; Maria Goudakou; Achilleas Papatheodorou; Yannis Prapas
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  25     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Iakentro Fertility Centre, Ag. Vasiliou 4 Street, Thessaloniki, Greece.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Embryo Implantation / drug effects*
Endometrium / drug effects
Fertility Agents, Female / administration & dosage
Fertilization in Vitro
Follicular Phase / drug effects*,  physiology
Infertility, Female / therapy
Menotropins / administration & dosage
Oocytes / drug effects,  physiology*
Pregnancy Rate
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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