Document Detail

Low-dose heparin thromboembolism prophylaxis.
MedLine Citation:
PMID:  8857904     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine a rational approach to heparin dosing for thromboembolism prophylaxis. DESIGN: Literature review. RESULTS: Three commonly used heparin dosing regimens were identified: (1) standard low-dose heparin (5000 U administered subcutaneously 2-3 times per day); (2) adjusted-dose heparin (adequate to elevate the activated partial thromboplastin time to 5 seconds above the upper limit of normal); and (3) low-molecular-weight heparin (30 mg subcutaneously twice daily without monitoring). CONCLUSIONS: Adjusted-dose heparin thromboembolism prophylaxis is both the safest and most reliable method currently available.
J T Owings; F W Blaisdell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  131     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-13     Completed Date:  1996-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1069-73     Citation Subset:  AIM; IM    
Department of Surgery, University of California, Davis, Medical Center, Sacramento, USA.
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MeSH Terms
Heparin / administration & dosage*
Heparin, Low-Molecular-Weight / administration & dosage
Injections, Subcutaneous
Partial Thromboplastin Time
Thromboembolism / prevention & control*
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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