Document Detail

Low-dose heparin prophylaxis and postoperative wound hematoma.
MedLine Citation:
PMID:  6662638     Owner:  NLM     Status:  MEDLINE    
In a randomized study, 124 patients, undergoing abdominal hysterectomy, were examined for postoperative wound hematoma after receiving low-dose heparin or heparin-dihydroergotamin (DHE) prophylaxis. Different sites of injection were chosen, with or without subcutaneous administration of thrombin at the end of surgery. The postoperative incidence of wound hematoma was not improved by subcutaneous thrombin administration. There was no difference between the two types of prophylaxis. When heparin or heparin/DHE was injected in the upper arm, however, fewer hematomas were found than after injection in the abdominal region. Investigations of the coagulation and fibrinolytic systems showed no difference between the two types of prophylaxis and injection site. The administration of thrombin did not cause intravascular activation of the coagulation system.
R C Briel
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International surgery     Volume:  68     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    1983 Jul-Sep
Date Detail:
Created Date:  1984-03-23     Completed Date:  1984-03-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-3     Citation Subset:  IM    
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MeSH Terms
Dihydroergotamine / therapeutic use*
Hematoma / prevention & control*
Heparin / administration & dosage*,  blood,  therapeutic use
Postoperative Complications / prevention & control*
Random Allocation
Reg. No./Substance:
511-12-6/Dihydroergotamine; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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