Document Detail

Low-dose heparin in thoracic surgery: effect on blood coagulation and fibrinolysis system.
MedLine Citation:
PMID:  6923655     Owner:  NLM     Status:  MEDLINE    
Plasma kallikrein, antithrombin III and antiplasmin were determined with chromogenic methods in 29 patients pre-, per- and post-operatively in a controlled, randomized study. 16 patients received calcium heparin, 5000 IU s. c. every 8 hr for 7 days, the first administration given 2 hr before surgical procedure. 13 control patients received saline. A significant reduction of kallikrein and antiplasmin in per- and post-operative periods was observed in the control patients compared with the heparin-treated patients, while there was a significant reduction of anti-thrombin III in the control patients compared with the treated patients only in the per-operative period. The results obtained suggest that activation of the coagulation and fibrinolysis system occurs in patients undergoing thoracic surgery, and that it is inhibited significantly by calcium heparin prophylaxis.
E M Pogliani; A Vigo; E Cofrancesco; M Colombi; G Cristoforetti; G Marchetti; G Vercesi; F Radaelli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis research     Volume:  27     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
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MeSH Terms
Antithrombin III / analysis
Blood Coagulation / drug effects*
Fibrinolysis / drug effects*
Heparin / administration & dosage,  pharmacology*
Kallikreins / blood
Middle Aged
Postoperative Period
Prekallikrein / analysis
Thoracic Surgery*
alpha-2-Antiplasmin / analysis
Reg. No./Substance:
0/alpha-2-Antiplasmin; 37270-89-6/calcium heparin; 9000-94-6/Antithrombin III; 9005-49-6/Heparin; 9055-02-1/Prekallikrein; EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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