Document Detail


Low-dose heparin in thoracic surgery: effect on blood coagulation and fibrinolysis system.
MedLine Citation:
PMID:  6923655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma kallikrein, antithrombin III and antiplasmin were determined with chromogenic methods in 29 patients pre-, per- and post-operatively in a controlled, randomized study. 16 patients received calcium heparin, 5000 IU s. c. every 8 hr for 7 days, the first administration given 2 hr before surgical procedure. 13 control patients received saline. A significant reduction of kallikrein and antiplasmin in per- and post-operative periods was observed in the control patients compared with the heparin-treated patients, while there was a significant reduction of anti-thrombin III in the control patients compared with the treated patients only in the per-operative period. The results obtained suggest that activation of the coagulation and fibrinolysis system occurs in patients undergoing thoracic surgery, and that it is inhibited significantly by calcium heparin prophylaxis.
Authors:
E M Pogliani; A Vigo; E Cofrancesco; M Colombi; G Cristoforetti; G Marchetti; G Vercesi; F Radaelli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis research     Volume:  27     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithrombin III / analysis
Blood Coagulation / drug effects*
Female
Fibrinolysis / drug effects*
Heparin / administration & dosage,  pharmacology*
Humans
Kallikreins / blood
Male
Middle Aged
Postoperative Period
Prekallikrein / analysis
Thoracic Surgery*
alpha-2-Antiplasmin / analysis
Chemical
Reg. No./Substance:
0/alpha-2-Antiplasmin; 37270-89-6/calcium heparin; 9000-94-6/Antithrombin III; 9005-49-6/Heparin; 9055-02-1/Prekallikrein; EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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