Document Detail

Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery.
MedLine Citation:
PMID:  7368149     Owner:  NLM     Status:  MEDLINE    
In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2,500 u pre-operatively then 5,000 u 12-hourly for 7 days) and 25 control patients received saline injections. All patients received a routine dose of intravenous sodium heparin intra-operatively. The trial was terminated because of excess bleeding complications in patients receiving subcutaneous heparin (8 vs. 1, p less than 0.05). Deep vein thrombosis occurred in 6 control patients and 2 patients on heparin (p less than 0.05). In this group of patients undergoing major vascular surgery the risk of bleeding due to heparin outweighed the potential benefit of thrombotic prophylaxis.
J J Belch; G D Lowe; J G Pollock; C D Forbes; C R Prentice
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  42     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1429-33     Citation Subset:  IM    
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MeSH Terms
Aorta / transplantation*
Dose-Response Relationship, Drug
Double-Blind Method
Hemorrhage / chemically induced
Heparin / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Postoperative Complications*
Thrombophlebitis / prevention & control*
Time Factors
Wounds and Injuries / etiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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