Document Detail


Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery.
MedLine Citation:
PMID:  7368149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2,500 u pre-operatively then 5,000 u 12-hourly for 7 days) and 25 control patients received saline injections. All patients received a routine dose of intravenous sodium heparin intra-operatively. The trial was terminated because of excess bleeding complications in patients receiving subcutaneous heparin (8 vs. 1, p less than 0.05). Deep vein thrombosis occurred in 6 control patients and 2 patients on heparin (p less than 0.05). In this group of patients undergoing major vascular surgery the risk of bleeding due to heparin outweighed the potential benefit of thrombotic prophylaxis.
Authors:
J J Belch; G D Lowe; J G Pollock; C D Forbes; C R Prentice
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  42     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1429-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aorta / transplantation*
Dose-Response Relationship, Drug
Double-Blind Method
Female
Hemorrhage / chemically induced
Heparin / administration & dosage*,  adverse effects,  therapeutic use
Humans
Male
Middle Aged
Postoperative Complications*
Thrombophlebitis / prevention & control*
Time Factors
Wounds and Injuries / etiology
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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