| Low-dose growth hormone and hypocaloric nutrition attenuate the protein-catabolic response after major operation. | |
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MedLine Citation:
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PMID: 2802836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of low-dose recombinant human growth hormone (GH) and hypocaloric nutrition on postoperative convalescence, we performed a placebo-controlled randomized double-blind trial in 18 patients after elective gastrectomy or colectomy. The subjects received parenteral nutrition containing 20 calories/kg per day and 1 g protein/kg per day. Daily injections of drug or placebo were given during the first postoperative week. The nine control subjects lost 3.3 kg (5.9% of preoperative weight) and had a cumulative nitrogen loss of 32.6 +/- 4.2 g nitrogen at eight days. The patients receiving GH lost significantly less weight (1.3 kg) and nitrogen loss was 7.1 +/- 3.1 g at eight days (p less than 0.001). Kinetic studies demonstrated that the anabolic effects of GH were associated with increased protein synthesis, and amino acid flux studies across the forearm revealed increased uptake of amino acid nitrogen in the GH-treated patients. Body compositional analysis revealed that the patients receiving GH maintained their lean body mass despite the major surgical procedure. Analysis of hand grip force showed a 10% loss of strength in the control subjects; with GH the patients maintained their grip force throughout the postoperative period. We conclude that the postoperative catabolic response can be modified with GH and hypocaloric nutrition. These metabolic and physiologic effects should now be studied in a larger number of patients to determine if this approach can reduce morbidity, mortality, and length of hospital stay for surgical patients. |
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Authors:
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Z M Jiang; G Z He; S Y Zhang; X R Wang; N F Yang; Y Zhu; D W Wilmore |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of surgery Volume: 210 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-10-28 Completed Date: 1989-10-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 513-24; discussion 524-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Peking Union Medical College Hospital, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Body Water Body Weight Colectomy* Diet* Double-Blind Method Energy Intake Gastrectomy* Growth Hormone / administration & dosage*, pharmacology Humans Middle Aged Nitrogen / metabolism Postoperative Care* Postoperative Period Proteins / metabolism* Random Allocation Recombinant Proteins / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Proteins; 0/Recombinant Proteins; 7727-37-9/Nitrogen; 9002-72-6/Growth Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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