| Low-dose gamma irradiation of food protein increases its allergenicity in a chronic oral challenge. | |
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MedLine Citation:
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PMID: 23000443 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Few chronic food protein models have described the relationship between allergenicity and the molecular structure of food protein after physical processing. The effect of γ- radiation on the structure of food protein was measured by fluorescence, circular dichroism and microcalorimetry. BALB/c mice were intraperitoneally sensitized and then given non-irradiated and irradiated Con-A by daily gavage for 28 days. The tendency to form insoluble amorphous aggregates and partially unfolded species was observed after irradiation. The administration of non-irradiated and irradiated samples at low-dose significantly increased weight loss as well as plasma levels of eotaxin in animals repeatedly exposed to Con-A. Significant lymphocytic infiltrate filling completely the stroma of microvilli and tubular glands was observed in the small intestinal of the group given Con-A irradiated at a low dose. This phenotype was not observed in animals treated with Con-A irradiated at a high dose. |
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Authors:
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A F M Vaz; M P Souza; P L Medeiros; A M M A Melo; R A Silva-Lucca; L A Santana; M L V Oliva; K R Perez; I M Cuccovia; M T S Correia |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-18 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Unidade Acadêmica de Medicina Veterinária, CSTR, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Brazil. Electronic address: melo_vaz@ig.com.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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