Document Detail


Low-dose gamma irradiation of food protein increases its allergenicity in a chronic oral challenge.
MedLine Citation:
PMID:  23000443     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Few chronic food protein models have described the relationship between allergenicity and the molecular structure of food protein after physical processing. The effect of γ- radiation on the structure of food protein was measured by fluorescence, circular dichroism and microcalorimetry. BALB/c mice were intraperitoneally sensitized and then given non-irradiated and irradiated Con-A by daily gavage for 28 days. The tendency to form insoluble amorphous aggregates and partially unfolded species was observed after irradiation. The administration of non-irradiated and irradiated samples at low-dose significantly increased weight loss as well as plasma levels of eotaxin in animals repeatedly exposed to Con-A. Significant lymphocytic infiltrate filling completely the stroma of microvilli and tubular glands was observed in the small intestinal of the group given Con-A irradiated at a low dose. This phenotype was not observed in animals treated with Con-A irradiated at a high dose.
Authors:
A F M Vaz; M P Souza; P L Medeiros; A M M A Melo; R A Silva-Lucca; L A Santana; M L V Oliva; K R Perez; I M Cuccovia; M T S Correia
Related Documents :
3432133 - A sex difference in the effect of cck-8 on food and water intake in obese (ob/ob) and l...
3994353 - Intramuscular ceruletide does not affect food intake in obese and non-obese human subje...
16812113 - Positive conditioned suppression: an explanation in terms of multiple and concurrent sc...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-18
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Unidade Acadêmica de Medicina Veterinária, CSTR, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Brazil. Electronic address: melo_vaz@ig.com.br.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes.
Next Document:  A detailed study of developmental immunotoxicity of imidacloprid in Wistar rats.