Document Detail


Low-dose gadobenate dimeglumine versus standard-dose gadopentate dimeglumine for delayed contrast-enhanced cardiac magnetic resonance imaging.
MedLine Citation:
PMID:  16777557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: The purpose of our study was to compare gadopentate dimeglumine (Gd-DTPA) and gadobenate dimeglumine (Gd-BOPTA) for the evaluation of myocardial infarction (MI) and in the grading transmural extent on late-contrast enhanced cardiac magnetic resonance imaging. MATERIALS AND METHODS: Twenty-three patients with clinically proven MI were examined with the use of 0.2 mmol/kg Gd-DTPA and 0.1 mmol/kg Gd-BOPTA in 2 days interval. All patients were examined with the use of segmented two-dimensional inversion-recovery turbo fast-field echo pulse sequence with an inversion time 210-300 milliseconds. Fifteen minutes time delay was used on both examinations after the injection of contrast agent. Contrast-to-noise ratio between normal myocardium and infarcted myocardium and signal intensity ratio (SIR) of the enhanced myocardium to blood pool was derived and compared for each contrast agent. RESULTS: A total of 61 infarcted segments were analyzed. All of the infarcted segments were visualized on both Gd-BOPTA and Gd-DTPA enhanced images. There was statistically no significant difference between 0.2 mmol/kg Gd-DTPA and 0.1 mmol/kg Gd-BOPTA in the mean contrast-to-noise ratio (10.19 versus 10.22; P = .96), SNR (14.29 versus 14.25; P = .96), and SIR (4.34 versus 4.21; P = .38) of the infarcted segments. Intraobserver agreement (kappa) between Gd-DTPA and Gd-BOPTA were R1 = 91% and R2 = 86%. Interobserver agreements between the readers were Gd-DTPA = 85% and Gd-BOPTA = 88%. CONCLUSION: According to our data, the diagnostic efficacy of 0.1 mmol/kg dose Gd-BOPTA is equivalent to that of 0.2 mmol/kg Gd-DTPA for the assessment of MI on delayed enhanced magnetic resonance images.
Authors:
Numan C Balci; Nagihan Inan; Yonca Anik; Mehmet S Erturk; Dilek Ural; Ali Demirci
Related Documents :
22275207 - Retinal imaging and image analysis.
21117597 - Spectral domain optical coherence tomography in the diagnosis and management of glaucoma.
22363837 - Effects of fluorescein staining on laser in vivo confocal microscopy images of the cornea.
1501527 - The accuracy of signal intensity measurements in magnetic resonance imaging as evaluate...
19574497 - Maturation of thalamic radiations between 34 and 41 weeks' gestation: a combined voxel-...
23165037 - 3d brain segmentation using dual-front active contours with optional user interaction.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  13     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-16     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  833-9     Citation Subset:  IM    
Affiliation:
Department of Radiology Saint Louis University, St. Louis, MO, USA. nbalci@slu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Contrast Media / administration & dosage*
Dose-Response Relationship, Drug
Female
Gadolinium DTPA / administration & dosage,  diagnostic use*
Humans
Magnetic Resonance Imaging*
Male
Meglumine / administration & dosage,  analogs & derivatives*,  diagnostic use
Middle Aged
Myocardial Infarction / diagnosis*
Organometallic Compounds / administration & dosage,  diagnostic use*
Sensitivity and Specificity
Time Factors
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Imaging liver metastases with a new oral manganese-based contrast agent.
Next Document:  Noninvasive gadolinium-enhanced three dimensional computed tomography coronary angiography.