| Low-dose follicle stimulating hormone for ovulation induction in polycystic ovary syndrome. | |
MedLine Citation:
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PMID: 7966037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 20 patients with clinically, sonographically and endocrinologically proven polycystic ovary syndrome, ovulation induction with low doses of follicle stimulating hormone (FSH) was attempted by administration for 27 menstrual cycles. One ampule FSH was administered from day 3 onwards. If the ovarian response was inadequate after days 10-12, the daily FSH dose was increased by half an ampule until ovulation induction. Of the cycles, 55.5% were monofollicular, whereas 4 cycles had to be cancelled due to a multifollicular response or failure of ovarian stimulation. On average, 14.4 ampules was used, and human chorionic gonadotropin was given on day 16. Seven pregnancies were established, with all of them ongoing at this writing. One twin pregnancy and one triplet pregnancy occurred. Even in polycystic ovary syndrome patients, low-dose administration of FSH allows safe stimulation, with a low incidence of ovarian hyperstimulation, a high pregnancy rate and an acceptably low risk of multiple pregnancies. |
Authors:
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T Strowitzki; D Seehaus; M Korell; H Hepp |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 39 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-12-08 Completed Date: 1994-12-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-503 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Klinikum Grosshadern, University of Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / therapeutic use Clinical Protocols Drug Therapy, Combination Female Follicle Stimulating Hormone / administration & dosage*, therapeutic use Humans Incidence Ovarian Hyperstimulation Syndrome / epidemiology, etiology Ovulation Induction / methods* Polycystic Ovary Syndrome / diagnosis, drug therapy* Pregnancy Pregnancy Outcome Pregnancy, Multiple Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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