Document Detail


Low-dose follicle stimulating hormone for ovulation induction in polycystic ovary syndrome.
MedLine Citation:
PMID:  7966037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 20 patients with clinically, sonographically and endocrinologically proven polycystic ovary syndrome, ovulation induction with low doses of follicle stimulating hormone (FSH) was attempted by administration for 27 menstrual cycles. One ampule FSH was administered from day 3 onwards. If the ovarian response was inadequate after days 10-12, the daily FSH dose was increased by half an ampule until ovulation induction. Of the cycles, 55.5% were monofollicular, whereas 4 cycles had to be cancelled due to a multifollicular response or failure of ovarian stimulation. On average, 14.4 ampules was used, and human chorionic gonadotropin was given on day 16. Seven pregnancies were established, with all of them ongoing at this writing. One twin pregnancy and one triplet pregnancy occurred. Even in polycystic ovary syndrome patients, low-dose administration of FSH allows safe stimulation, with a low incidence of ovarian hyperstimulation, a high pregnancy rate and an acceptably low risk of multiple pregnancies.
Authors:
T Strowitzki; D Seehaus; M Korell; H Hepp
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  39     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-08     Completed Date:  1994-12-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-503     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Klinikum Grosshadern, University of Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Gonadotropin / therapeutic use
Clinical Protocols
Drug Therapy, Combination
Female
Follicle Stimulating Hormone / administration & dosage*,  therapeutic use
Humans
Incidence
Ovarian Hyperstimulation Syndrome / epidemiology,  etiology
Ovulation Induction / methods*
Polycystic Ovary Syndrome / diagnosis,  drug therapy*
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple
Treatment Failure
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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