| Low dose of fentanyl reduces predicted effect-site concentration of propofol for flexible laryngeal mask airway insertion. | |
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MedLine Citation:
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PMID: 19444558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: In contrast to reports on the classical laryngeal mask airway (classical LMA; CLMA), no report has calculated the 50% and 95% effect-site concentrations (EC(50) and EC(95), respectively) of propofol required for flexible LMA (FLMA) insertion. This study was designed to determine the EC(50) and EC(95) of propofol for FLMA insertion, using probit analysis, and to investigate whether supplemental 0.25 microg x kg(-1) fentanyl decreased these concentrations. METHODS: Fifty-nine unpremedicated patients who were scheduled for elective minor oral surgery were randomly allocated to a saline-propofol group (S-P group; n = 30) or a fentanyl-propofol group (F-P group; n = 29). Each group was further divided into four subgroups, in which the propofol EC for FLMA insertion was set at 2.5, 3.0, 3.5, and 4.0 microg x ml(-1), respectively, in the S-P group and 1.8, 2.0, 2.5, and 3.0 microg x ml(-1), respectively, in the F-P group. The experiment was assessed as "successful" when FLMA insertion within 1 min was possible. RESULTS: The EC(50) and EC(95) in the S-P group were 3.29 (95% confidence interval [CI], 2.83-3.93) and 4.73 (95% CI, 3.94-12.22) microg x ml(-1), and those in the F-P group were 2.13 (95% CI, 1.42-2.60) and 3.54 95% CI, (2.78-34.78) microg x ml(-1), respectively. The EC(50) in the F-P group was significantly lower than that in the S-P group. There were no significant differences in bispectral index (BIS), hemodynamic variables, respiratory rate, and arterial oxygen saturation (SpO2) between the S-P and F-P groups. CONCLUSION: The propofol EC(50) for FLMA insertion was decreased by supplemental 0.25 microg x kg(-1) fentanyl without BIS, hemodynamic, or respiratory depression. |
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Authors:
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Junko Yumura; Yoshihiko Koukita; Ken-ichi Fukuda; Yuzuru Kaneko; Tatsuya Ichinohe |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-05-15 |
Journal Detail:
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Title: Journal of anesthesia Volume: 23 ISSN: 1438-8359 ISO Abbreviation: J Anesth Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
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Languages: eng Pagination: 203-8 Citation Subset: IM |
Affiliation:
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Department of Dental Anesthesiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Algorithms Anesthetics, Intravenous / pharmacokinetics* Dose-Response Relationship, Drug Double-Blind Method Electroencephalography / drug effects Female Fentanyl / pharmacology* Hemodynamics / drug effects Humans Hypnotics and Sedatives / pharmacokinetics* Laryngeal Masks* Male Middle Aged Oral Surgical Procedures Oxygen / blood Preanesthetic Medication Propofol / pharmacokinetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 2078-54-8/Propofol; 437-38-7/Fentanyl; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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