Document Detail

Low dose of fentanyl reduces predicted effect-site concentration of propofol for flexible laryngeal mask airway insertion.
MedLine Citation:
PMID:  19444558     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In contrast to reports on the classical laryngeal mask airway (classical LMA; CLMA), no report has calculated the 50% and 95% effect-site concentrations (EC(50) and EC(95), respectively) of propofol required for flexible LMA (FLMA) insertion. This study was designed to determine the EC(50) and EC(95) of propofol for FLMA insertion, using probit analysis, and to investigate whether supplemental 0.25 microg x kg(-1) fentanyl decreased these concentrations. METHODS: Fifty-nine unpremedicated patients who were scheduled for elective minor oral surgery were randomly allocated to a saline-propofol group (S-P group; n = 30) or a fentanyl-propofol group (F-P group; n = 29). Each group was further divided into four subgroups, in which the propofol EC for FLMA insertion was set at 2.5, 3.0, 3.5, and 4.0 microg x ml(-1), respectively, in the S-P group and 1.8, 2.0, 2.5, and 3.0 microg x ml(-1), respectively, in the F-P group. The experiment was assessed as "successful" when FLMA insertion within 1 min was possible. RESULTS: The EC(50) and EC(95) in the S-P group were 3.29 (95% confidence interval [CI], 2.83-3.93) and 4.73 (95% CI, 3.94-12.22) microg x ml(-1), and those in the F-P group were 2.13 (95% CI, 1.42-2.60) and 3.54 95% CI, (2.78-34.78) microg x ml(-1), respectively. The EC(50) in the F-P group was significantly lower than that in the S-P group. There were no significant differences in bispectral index (BIS), hemodynamic variables, respiratory rate, and arterial oxygen saturation (SpO2) between the S-P and F-P groups. CONCLUSION: The propofol EC(50) for FLMA insertion was decreased by supplemental 0.25 microg x kg(-1) fentanyl without BIS, hemodynamic, or respiratory depression.
Junko Yumura; Yoshihiko Koukita; Ken-ichi Fukuda; Yuzuru Kaneko; Tatsuya Ichinohe
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-05-15
Journal Detail:
Title:  Journal of anesthesia     Volume:  23     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-15     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
Department of Dental Anesthesiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan.
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MeSH Terms
Anesthetics, Intravenous / pharmacokinetics*
Dose-Response Relationship, Drug
Double-Blind Method
Electroencephalography / drug effects
Fentanyl / pharmacology*
Hemodynamics / drug effects
Hypnotics and Sedatives / pharmacokinetics*
Laryngeal Masks*
Middle Aged
Oral Surgical Procedures
Oxygen / blood
Preanesthetic Medication
Propofol / pharmacokinetics*
Young Adult
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 2078-54-8/Propofol; 437-38-7/Fentanyl; 7782-44-7/Oxygen

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