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LOW-DOSE ENALAPRIL REDUCES ANGIOTENSIN II AND ATTENUATES DIABETIC-INDUCED CARDIAC AND AUTONOMIC DYSFUNCTIONS.
MedLine Citation:
PMID:  21921804     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: Activation of renin-angiotensin system has been linked to cardiovascular and autonomic dysfunctions in diabetes. Experiments were performed to investigate the effects of angiotensin-converting enzyme inhibitor Enalapril (ACEI) on cardiac and autonomic functions in diabetic rats. Diabetes was induced by streptozotocin (50 mg/kg), and rats were treated with Enalapril (1 mg/kg/day). After 30 days, evaluations were performed in control, diabetic, and Enalapril-treated groups. Cardiac function was evaluated by echocardiography and through cannulation of the left ventricle (at baseline and in response to volume overload). Heart rate and systolic blood pressure variabilities were evaluated in the time and frequency domains. Streptozotocin rats had left ventricular systolic and diastolic dysfunctions, expressed by reduced ejection fraction and increased isovolumic relaxation time. The ACEI prevented these changes, improved diastolic cardiac responses to volume overload and total power of heart rate variability, reduced the ACE1activity and protein expression, cardiac Angiotensin II levels, and increased ACE2 activity, despite unchanged blood pressure. Correlations were obtained between Angiotensin II content with systolic and diastolic functions and heart rate variability. These findings provide evidence that the low-dose ACEI prevents autonomic and cardiac dysfunctions induced by diabetes without changing blood pressure and associated with reduced cardiac Angiotensin II and increased ACE2 activity.
Authors:
Christiane Malfitano; Kátia De Angelis; Tiago Fernandes; Rogério Brandão Wichi; Kaleizu Rosa; Mariana Pazzine; Cristiano Mostarda; Fernanda Aparecida Ronchi; Edilamar Menezesde Oliveira; Dulce Elena Casarini; Maria-Cláudia Irigoyen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-14
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Hypertension Unit, Heart Institute (InCor), University of São Paulo, Medical School, São Paulo, Brazil 2Federal University of São Paulo, Nephrology Department, São Paulo, Brazil 3PROCAD - Cardiology Institute, University Cardiology Foundation, Porto Alegre, Brazil 4University Nove de Julho, São Paulo, Brazil 5School of Physical Education and Sports of University of São Paulo, São Paulo, Brazil.
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