| Low-dose dexamethasone suppression test in chronic fatigue syndrome and health. | |
| | |
MedLine Citation:
|
PMID: 11914448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Subtle dysregulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome have been described. The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome. METHODS: In 21 patients with chronic fatigue syndrome and 21 healthy control subjects, awakening and circadian salivary free cortisol profiles were assessed over 2 consecutive days and compared with awakening and circadian salivary free cortisol profiles after administration of 0.5 mg of dexamethasone at 11:00 PM the previous day. RESULTS: Patients with chronic fatigue syndrome had normal salivary free cortisol profiles but showed enhanced and prolonged suppression of salivary free cortisol after the administration of 0.5 mg of dexamethasone in comparison to the control subjects. CONCLUSIONS: Enhanced negative feedback of the hypothalamus-pituitary-adrenal axis could be a plausible explanation for the previously described alterations in hypothalamus-pituitary-adrenal axis functioning in chronic fatigue syndrome. Because similar changes have been described in stress-related disorders, a putative role of stress in the pathogenesis of the enhanced feedback is possible. |
| | |
Authors:
|
Jens Gaab; Dominik Hüster; Renate Peisen; Veronika Engert; Tanja Schad; Thomas H Schürmeyer; Ulrike Ehlert |
Related Documents
:
|
11873498 - Radiophobia: long-term psychological consequences of chernobyl. 6464618 - Ultrastructural damage of crural muscle in post-thrombotic syndrome. 20941678 - Treatment of chronic immune-mediated neuropathies: chronic inflammatory demyelinating p... 9135918 - Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. 1937068 - Receptor function of low-density lipoproteins in werner's syndrome. 16282778 - Velo-cardio-facial syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Psychosomatic medicine Volume: 64 ISSN: 0033-3174 ISO Abbreviation: Psychosom Med Publication Date: 2002 Mar-Apr |
Date Detail:
|
Created Date: 2002-03-26 Completed Date: 2002-05-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
|
Languages: eng Pagination: 311-8 Citation Subset: IM |
Affiliation:
|
Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany. jgaab@klipsy.unizh.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Dexamethasone / diagnostic use* Fatigue Syndrome, Chronic / diagnosis*, physiopathology, psychology Female Humans Hydrocortisone / metabolism* Hypothalamo-Hypophyseal System / physiopathology Male Pituitary-Adrenal System / physiopathology Reference Values Saliva / metabolism |
| Chemical | |
Reg. No./Substance:
|
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reactivity and vulnerability to stress-associated risk for upper respiratory illness.
Next Document: Prognosis of chronic fatigue in a community-based sample.