Document Detail

Low-dose dexamethasone suppression test in chronic fatigue syndrome and health.
MedLine Citation:
PMID:  11914448     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Subtle dysregulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome have been described. The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome. METHODS: In 21 patients with chronic fatigue syndrome and 21 healthy control subjects, awakening and circadian salivary free cortisol profiles were assessed over 2 consecutive days and compared with awakening and circadian salivary free cortisol profiles after administration of 0.5 mg of dexamethasone at 11:00 PM the previous day. RESULTS: Patients with chronic fatigue syndrome had normal salivary free cortisol profiles but showed enhanced and prolonged suppression of salivary free cortisol after the administration of 0.5 mg of dexamethasone in comparison to the control subjects. CONCLUSIONS: Enhanced negative feedback of the hypothalamus-pituitary-adrenal axis could be a plausible explanation for the previously described alterations in hypothalamus-pituitary-adrenal axis functioning in chronic fatigue syndrome. Because similar changes have been described in stress-related disorders, a putative role of stress in the pathogenesis of the enhanced feedback is possible.
Jens Gaab; Dominik Hüster; Renate Peisen; Veronika Engert; Tanja Schad; Thomas H Schürmeyer; Ulrike Ehlert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  64     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany.
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MeSH Terms
Dexamethasone / diagnostic use*
Fatigue Syndrome, Chronic / diagnosis*,  physiopathology,  psychology
Hydrocortisone / metabolism*
Hypothalamo-Hypophyseal System / physiopathology
Pituitary-Adrenal System / physiopathology
Reference Values
Saliva / metabolism
Reg. No./Substance:
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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