Document Detail


Low-dose dexamethasone ameliorates circulatory failure and renal dysfunction in conscious rats with endotoxemia.
MedLine Citation:
PMID:  15087827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corticosteroids have long been proposed as a therapeutic adjuvant in septic renal dysfunction because of their anti-inflammatory properties and favorable results from animal experiments. However, some reports suggested the potential for harm associated with the administration of early high-dose corticosteroids in patients with severe sepsis and septic shock. Thus, we examined the effects of low-dose dexamethasone (0.01 and 0.1 mg/kg) on hemodynamics and renal function in conscious rats with endotoxemia. Intravenous injection of rats with endotoxin (E. coli lipopolysaccharide, LPS, 1 mg/kg) caused hypotension, vascular hyporeactivity, and tachycardia as well as renal dysfunction. Circulatory failure and renal dysfunction caused by LPS were significantly attenuated in the dexamethasone 0.1 mg/kg-treated group. The nitric oxide (NO) production in plasma and renal tissue and the iNOS protein expression in the kidney were suppressed by cotreatment of LPS rats with dexamethasone, 0.1 mg/kg. Light microscopy showed that 0.1 mg/kg dexamethasone reduced marked infiltration of neutrophils in renal tissues from LPS rats. Moreover, the survival rate at 18 h was significantly increased in the dexamethasone 0.1 mg/kg-treated group when compared with the LPS group. These results suggest that the beneficial effects of low-dose dexamethasone (0.1 mg/kg) in conscious rats with endotoxic shock are associated with amelioration of circulatory failure and renal dysfunction, and this is attributed to inhibition of NO production.
Authors:
Cheng-Ming Tsao; Shung-Tai Ho; Ann Chen; Jhi-Joung Wang; Chi-Yuan Li; Shen-Kou Tsai; Chin-Chen Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  21     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484-91     Citation Subset:  IM    
Affiliation:
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Republic of China, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / metabolism
Blood Pressure
Blotting, Western
Calcium / blood
Dexamethasone / therapeutic use*
Endotoxemia / drug therapy*
Escherichia coli / metabolism
Glucocorticoids / therapeutic use
Hydrogen-Ion Concentration
Kidney / injuries*,  microbiology*,  pathology
Lipopolysaccharides / metabolism
Male
Neutrophils / metabolism
Nitrates / metabolism
Nitric Oxide / metabolism
Nitrites / metabolism
Oxygen / metabolism
Potassium / blood
Rats
Rats, Wistar
Sepsis / drug therapy
Shock, Septic / therapy
Tachycardia
Time Factors
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Lipopolysaccharides; 0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide; 50-02-2/Dexamethasone; 7440-09-7/Potassium; 7440-70-2/Calcium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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