Document Detail

Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks.
MedLine Citation:
PMID:  10063787     Owner:  NLM     Status:  MEDLINE    
To assess the efficacy and safety of bisoprolol/6.25-mg hydrochlorothiazide (HCTZ), amlodipine, and enalapril in black and nonblack patients, data from two comparative studies were pooled and subgroup analyses performed. Both studies had similar designs and included all three active treatments. The second study also included a placebo group. Subjects (n = 541) with a sitting diastolic blood pressure of 95-114 mmHg were titrated to achieve a diastolic blood pressure < or = 90 mmHg. The studies included 114 blacks and 427 nonblacks. Results of an intention-to-treat analysis of mean change from baseline after 12 weeks of treatment showed the following: 1) blood pressure was significantly lowered by all three active drugs compared with baseline or placebo; 2) in blacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reductions of systolic and diastolic blood pressure than enalapril or placebo, but was not significantly different from amlodipine; 3) in nonblacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reduction of diastolic blood pressure than amlodipine, enalapril, or placebo. The placebo-corrected change in blood pressure was greater for blacks than whites on the bisoprolol/6.25-mg HCTZ combination, but this was not statistically significant. Bisoprolol/6.25-mg HCTZ controlled diastolic blood pressure to < or = 90 mmHg in significantly more patients than enalapril or placebo in blacks and nonblacks. The difference in control rates was not significant versus amlodipine. The incidence of drug-related adverse events was similar between treatments; however, bisoprolol/6.25-mg HCTZ had a lower discontinuation rate due to lack of blood pressure control or adverse experiences in both blacks and nonblacks.
L M Prisant; J M Neutel; K Ferdinand; V Papademetriou; V DeQuattro; W D Hall; M R Weir
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  91     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-15     Completed Date:  1999-04-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-8     Citation Subset:  IM    
Section of Cardiology, Medical College of Georgia, Augusta 30912-3105, USA.
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MeSH Terms
African Continental Ancestry Group*
Amlodipine / therapeutic use
Analysis of Variance
Antihypertensive Agents / therapeutic use*
Bisoprolol / therapeutic use
Chi-Square Distribution
Double-Blind Method
Drug Therapy, Combination
Enalapril / therapeutic use
Hydrochlorothiazide / therapeutic use
Hypertension / drug therapy*,  ethnology*
Middle Aged
Reg. No./Substance:
0/Antihypertensive Agents; 58-93-5/Hydrochlorothiazide; 66722-44-9/Bisoprolol; 75847-73-3/Enalapril; 88150-42-9/Amlodipine

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