| Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study. | |
| | |
MedLine Citation:
|
PMID: 20943705 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Low-dose aspirin therapy could improve remodelling of maternal spiral arteries during early placentation and prevent subsequent pregnancy-related hypertensive disorders. We investigated whether low-dose aspirin therapy reduces the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients when medication was started prior to pregnancy. METHODS: A total of 487 patients who underwent IVF/ICSI were randomized to receive 100 mg aspirin (n = 242) or placebo (n = 245) daily, starting on the first day of gonadotrophin stimulation. Pregnant women continued the medication until delivery. A total of 107 patients (52 with aspirin and 55 with placebo) experienced live birth and were included in this follow-up study. The main outcome measure was the incidence of hypertensive pregnancy complications. RESULTS: Embryo transfer took place in 227 (94%) women in the aspirin group and in 229 (93%) women in the placebo group. The live birth rate between the aspirin (22.9%) and placebo (24.0%) groups did not differ significantly (P = 0.78). The overall incidence of hypertensive pregnancy complications was 15.4% (8/52) in the aspirin group and 18.2% (10/55) in the placebo group (P = 0.70, 95% confidence interval for the difference of proportions -17 to 11%). There were two cases of severe pre-eclampsia in the aspirin group and three cases in the placebo group. CONCLUSIONS: In the present study, the incidence of hypertensive pregnancy complications did not differ statistically significantly between low-dose aspirin and placebo groups in unselected IVF/ICSI patients, when medication was started concomitantly with gonadotrophin stimulation and continued until delivery. The study was registered at clinicaltrials.gov. NCT00683202. |
| | |
Authors:
|
Mervi Haapsamo; Hannu Martikainen; Helena Tinkanen; Seppo Heinonen; Sinikka Nuojua-Huttunen; Juha Räsänen |
Related Documents
:
|
9211675 - Trial of calcium to prevent preeclampsia. 7657015 - Atrial natriuretic peptide plasma level remains unchanged in various hypertensive disor... 2845675 - Fetal endoxins and complications of pregnancy. 11435745 - Factor analysis, including antihypertensive medication, of the outcome of pregnancy in ... 16959805 - Uptake and distribution of catechins in fetal organs following in utero exposure in rats. 14672475 - Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
|
Title: Human reproduction (Oxford, England) Volume: 25 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
|
Languages: eng Pagination: 2972-7 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland. mervi.haapsamo@oulu.fi |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00683202 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhal...
Next Document: No influence of body mass index on first trimester fetal growth.