Document Detail


Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study.
MedLine Citation:
PMID:  20943705     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Low-dose aspirin therapy could improve remodelling of maternal spiral arteries during early placentation and prevent subsequent pregnancy-related hypertensive disorders. We investigated whether low-dose aspirin therapy reduces the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients when medication was started prior to pregnancy.
METHODS: A total of 487 patients who underwent IVF/ICSI were randomized to receive 100 mg aspirin (n = 242) or placebo (n = 245) daily, starting on the first day of gonadotrophin stimulation. Pregnant women continued the medication until delivery. A total of 107 patients (52 with aspirin and 55 with placebo) experienced live birth and were included in this follow-up study. The main outcome measure was the incidence of hypertensive pregnancy complications.
RESULTS: Embryo transfer took place in 227 (94%) women in the aspirin group and in 229 (93%) women in the placebo group. The live birth rate between the aspirin (22.9%) and placebo (24.0%) groups did not differ significantly (P = 0.78). The overall incidence of hypertensive pregnancy complications was 15.4% (8/52) in the aspirin group and 18.2% (10/55) in the placebo group (P = 0.70, 95% confidence interval for the difference of proportions -17 to 11%). There were two cases of severe pre-eclampsia in the aspirin group and three cases in the placebo group.
CONCLUSIONS: In the present study, the incidence of hypertensive pregnancy complications did not differ statistically significantly between low-dose aspirin and placebo groups in unselected IVF/ICSI patients, when medication was started concomitantly with gonadotrophin stimulation and continued until delivery. The study was registered at clinicaltrials.gov. NCT00683202.
Authors:
Mervi Haapsamo; Hannu Martikainen; Helena Tinkanen; Seppo Heinonen; Sinikka Nuojua-Huttunen; Juha Räsänen
Related Documents :
9211675 - Trial of calcium to prevent preeclampsia.
7657015 - Atrial natriuretic peptide plasma level remains unchanged in various hypertensive disor...
2845675 - Fetal endoxins and complications of pregnancy.
11435745 - Factor analysis, including antihypertensive medication, of the outcome of pregnancy in ...
16959805 - Uptake and distribution of catechins in fetal organs following in utero exposure in rats.
14672475 - Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-13
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2972-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland. mervi.haapsamo@oulu.fi
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00683202
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Y chromosome microdeletions are not associated with spontaneous recurrent pregnancy loss in a Sinhal...
Next Document:  No influence of body mass index on first trimester fetal growth.